Clinical characteristics and change in the antibody titres of patients with anti-MDA5 antibody-positive inflammatory myositis

Rheumatology
Yoshiyuki AbeNaoto Tamura

Abstract

The aim of this study was to evaluate the clinical characteristics of patients with anti-melanoma differentiation-associated gene 5 (MDA5) antibody-positive inflammatory myositis, and the change in anti-MDA5 antibody titres before and after onset. For 105 PM/DM patients, newly diagnosed in our hospital within the period 2008-2016, serum anti-MDA5 antibody levels were measured at diagnosis and after treatment by ELISA using the MESACUP anti-MDA5 test. The relationships between anti-MDA5 antibody levels and clinical manifestations, laboratory data, and mortality were examined. Compared with patients who were anti-MDA5 antibody negative, those who were antibody positive demonstrated more frequent dermatitis, clinically amyopathic DM, interstitial lung disease and rapid-progressive interstitial lung disease, as well as significantly higher serum ferritin, significantly lower creatine kinase and aldolase, and significantly less frequent ANA (⩾1:160) and anti-cytoplasmic pattern of ANA staining positivity. Anti-MDA5 antibody titres were examined before disease onset in two patients; one showed antibody positivity with low titres 2 years earlier, while both exhibited increased titres at onset. Anti-MDA5 antibody titres declined signif...Continue Reading

References

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Citations

Apr 11, 2018·Current Rheumatology Reports·Paige W Wolstencroft, David F Fiorentino
Aug 31, 2018·Fukushima Journal of Medical Science·Makiko YashiroKiyoshi Migita
Jun 28, 2019·International Journal of Rheumatic Diseases·Yasuhito HamaguchiKazuhiko Takehara
Mar 3, 2020·Rheumatology·Jean-Baptiste VulstekeEllen De Langhe
Sep 30, 2020·Journal of Korean Medical Science·Ga Young AhnDae Hyun Yoo
Jan 7, 2021·Clinical Reviews in Allergy & Immunology·Wanlong WuShuang Ye
Dec 4, 2019·Neuromuscular Disorders : NMD·Andrew L MammenUNKNOWN ENMC 239th Workshop Study Group
Mar 10, 2020·Modern Rheumatology·Koichi YamaguchiToshitaka Maeno
Jan 1, 2021·Seminars in Arthritis and Rheumatism·Kun-Yan SunGuang-Fa Wang
Mar 28, 2021·Communications Biology·Spyridon MegremisJanine A Lamb

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