Clinical Characteristics and Cytokine Profiles of Organizing Pneumonia in Patients with Rheumatoid Arthritis Treated with or without Biologics

The Journal of Rheumatology
Hidenaga KawasumiHisashi Yamanaka

Abstract

It has been reported that organizing pneumonia (OP) develops when patients with rheumatoid arthritis (RA) are treated with biologic disease-modifying antirheumatic drugs (bDMARD). However, the clinical characteristics and pathophysiology of OP in RA remain unknown in patients treated with bDMARD. We investigated the clinical characteristics and cytokine profiles of patients with RA-OP treated with bDMARD or conventional synthetic DMARD (csDMARD). Twenty-four patients with RA who had developed OP were enrolled. These patients included 12 treated with bDMARD (bDMARD-OP subset) and 12 treated with csDMARD (csDMARD-OP subset). We compared the clinical characteristics and cytokine profiles between the patients with OP (OP subset, n = 24) and non-OP patients (non-OP subset, n = 29). There was no significant difference in clinical characteristics between the OP subset and the non-OP subset. Four patients developed OP within 2 months of bDMARD administration. In the other 8 patients, OP developed more than 1 year after the initiation of bDMARD. OP improved with corticosteroid treatment in all bDMARD-OP patients. After OP improved, bDMARD were readministered in 6 patients, and no OP recurrence was observed in any of these patients. Our ...Continue Reading

References

May 1, 1991·Respiratory Medicine·J H ReesR M du Bois
Mar 13, 1999·Annals of Internal Medicine·L W MorelandM E Weinblatt
Jan 1, 2005·Rheumatology International·Paola CaramaschiLisa Maria Bambara
Aug 27, 2005·The British Journal of Dermatology·A MastroianniE Berardesca
Aug 2, 2006·The European Respiratory Journal·J-F Cordier
Aug 16, 2006·Rheumatology·A YoungUNKNOWN Early Rheumatoid Arthritis Study (ERAS) group
Jan 16, 2008·The American Journal of the Medical Sciences·Fotis DrakopanagiotakisMarc A Judson
Apr 2, 2008·Rheumatology International·Savvas IoannouGeorge E Tzelepis
Apr 19, 2008·BMC Musculoskeletal Disorders·Alberto Alonso-RuizAntonio Quintana
May 27, 2008·Rheumatology International·Javier Alberto CavallascaGuillermo Alberto Tate
Jan 12, 2010·Rheumatology International·Soo-Kyung ChoYoon-Kyoung Sung
Aug 10, 2010·Clinics in Chest Medicine·Danielle Antin-OzerkisRichard A Matthay
Oct 27, 2010·Journal of Biomedicine & Biotechnology·Ching-Chang ChengYung-Tsung Chiu
Oct 4, 2011·Internal Medicine·Kayoko IkegawaKeishi Kubo
Jul 21, 2012·Nature Immunology·Dario A A Vignali, Vijay K Kuchroo

❮ Previous
Next ❯

Citations


❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.