Clinical characteristics and diagnosis of a rare case of systemic AL amyloidosis: a descriptive study

Oncotarget
Pengguo ChenJianfang Hu

Abstract

Systemic amyloidosis is a rare disease involving multiple organs. It is difficult to establish diagnosis as the symptoms is diverse and non-specific. And without specific therapy the prognosis is very poor. We analyzed detailed clinical and laboratorial data of a 53-year-old male patient. The characteristic features included refractory pleural effusion, extraordinary hepatomegaly and cardiac failure. The illness lasted 9 months and therapy period spanned 4 months. Fine needle biopsy of liver, lung, heart, pancreas and kidney was performed. Immunohistochemistry, immunofluorescence, Congo staining and hematoxylin and eosin staining were performed. All specimens were stained pink with haematoxylin and eosin staining. Amorphous deposits of eosinophilic material were visible within the Congo red dye stained liver tissue whereas under cross-polarized light pathognomonic apple-green birefringence of amyloid deposits was visible. At last systemic AL amyloidosis diagnosis was confirmed. The report showed an unusual AL amyloidosis case in detail which would be helpful for physician in clinical work.

References

Sep 15, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Angela DispenzieriAllan S Jaffe
Sep 28, 2005·Circulation·Rodney H Falk
Feb 18, 2006·Current Opinion in Pharmacology·Helen J Lachmann, Philip N Hawkins
Jun 8, 2007·The New England Journal of Medicine·Helen J LachmannPhilip N Hawkins
Nov 27, 2007·Journal of the American College of Cardiology·Joseph B SelvanayagamStefan Neubauer
Jul 30, 2009·Journal of Clinical Pathology·M DeshmukhK N Naresh
Oct 13, 2011·Journal of Internal Medicine·P T SattianayagamJ D Gillmore
Aug 28, 2013·Nature Reviews. Nephrology·Julian D Gillmore, Philip N Hawkins
Oct 23, 2013·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Taxiarchis V KourelisAngela Dispenzieri
Jun 3, 2014·Molecular Cancer·Mildred FelderManish S Patankar
Jan 1, 2014·Central-European Journal of Immunology·Sonia JerzykowskaMieczysław A Komarnicki
Jan 1, 2016·Lancet·Ashutosh D WechalekarPhilip N Hawkins

❮ Previous
Next ❯

Citations

Jul 2, 2020·Cells·Mohammed M H AsiriJo W M Höppener

❮ Previous
Next ❯

Methods Mentioned

BETA
ESR
biopsy

Related Concepts

Related Feeds

Cardiac Amyloidosis

Cardiac amyloidosis is a myocardial disease characterized by extracellular amyloid infiltration throughout the heart. Discover the latest research on cardiac amyloidosis here.

Related Papers

Kidney International
Alexander J Howie, Mared P Owen-Casey
American Journal of Otolaryngology
Kristen S FahrnerBenoit J Gosselin
The American Review of Respiratory Disease
L R KlineJ H Hansen-Flaschen
Romanian Journal of Morphology and Embryology = Revue Roumaine De Morphologie Et Embryologie
Irina Iuliana CostacheAnca Sava
Nihon Kokyūki Gakkai zasshi = the journal of the Japanese Respiratory Society
Akihisa SutaniYoshio Sakamoto
© 2022 Meta ULC. All rights reserved