Clinical Characteristics and Functional Motor Outcomes of Enterovirus 71 Neurological Disease in Children

JAMA Neurology
Hooi-Ling TeohHugo Sampaio

Abstract

Enterovirus 71 (EV71) causes a spectrum of neurological complications with significant morbidity and mortality. Further understanding of the characteristics of EV71-related neurological disease, factors related to outcome, and potential responsiveness to treatments is important in developing therapeutic guidelines. To further characterize EV71-related neurological disease and neurological outcome in children. Prospective 2-hospital (The Sydney Children's Hospitals Network) inpatient study of 61 children with enterovirus-related neurological disease during a 2013 outbreak of EV71 in Sydney, Australia. The dates of our analysis were January 1, to June 30, 2013. Clinical, neuroimaging, laboratory, and pathological characteristics, together with treatment administered and functional motor outcomes, were assessed. Among 61 patients, there were 4 precipitous deaths (7%), despite resuscitation at presentation. Among 57 surviving patients, the age range was 0.3 to 5.2 years (median age, 1.5 years), and 36 (63%) were male. Fever (100% [57 of 57]), myoclonic jerks (86% [49 of 57]), ataxia (54% [29 of 54]), and vomiting (54% [29 of 54]) were common initial clinical manifestations. In 57 surviving patients, EV71 neurological disease includ...Continue Reading

Citations

Sep 13, 2016·International Journal of Environmental Research and Public Health·Ping-Chin ChangKow-Tong Chen
Mar 28, 2017·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·D Casas-AlbaC Launes
Feb 18, 2017·Current Opinion in Neurology·Fenella J Kirkham
Jun 24, 2017·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·E W AndersenM M Ryan
Oct 14, 2017·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Pin Fee ChongUNKNOWN Acute Flaccid Myelitis Collaborative Study Investigators
Dec 21, 2018·BMJ : British Medical Journal·Sacha Stelzer-Braid, William Rawlinson
May 3, 2019·BMC Infectious Diseases·Lea Necitas ApostolHitoshi Oshitani
Aug 14, 2019·Current Opinion in Pediatrics·Douglas G PostelsKerri L LaRovere
Sep 10, 2020·Journal of Paediatrics and Child Health·Junchao BaoPhilip N Britton
Jul 17, 2020·Journal of Neurovirology·Ryoko NakamuraRyutaro Kira
Dec 23, 2016·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·Gonçalo CaçãoJoana Damásio
Jul 14, 2020·Journal of Clinical Neurology·Xiang Fang, Ruksana Huda
Sep 1, 2018·Journal of Tropical Pediatrics·Syed N SarmastAsha Benakappa
Jul 1, 2018·Current Infectious Disease Reports·Ari Bitnun, E Ann Yeh
Mar 20, 2019·Journal of the Pediatric Infectious Diseases Society·Janet R Gilsdorf
Oct 20, 2019·Journal of Biomedical Science·Jiratchaya PuenpaYong Poovorawan
Jul 23, 2020·Virologica Sinica·Xiaoman WoWenran Zhao
Jun 22, 2017·Neural Plasticity·Hooi Ling TeohMichelle Farrar
Jan 13, 2018·International Journal of Molecular Medicine·Ioannis N MammasDemetrios A Spandidos
Dec 16, 2018·Virologica Sinica·Huiqiang Wang, Yuhuan Li
Dec 19, 2018·Emerging Infectious Diseases·Carmen Niño TaravillaAna Serrano González
Jun 11, 2019·Frontiers in Neurology·Elba Pascual-GoñiEulàlia Turón-Viñas
Dec 12, 2018·Developmental Medicine and Child Neurology·Esther M TantsisUNKNOWN Paediatric Myelitis Mri Study Group
Nov 7, 2019·Current Opinion in Pediatrics·Douglas G PostelsKerri L LaRovere
Jun 15, 2020·Journal of the Pediatric Infectious Diseases Society·Brittany S PassiakNgocHanh Vu
Mar 18, 2020·Communicable Diseases Intelligence·Junchao BaoPhillip N Britton
Dec 2, 2020·Microorganisms·David M BrownRichard H Scheuermann
Dec 4, 2019·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Sacha Stelzer-BraidWilliam D Rawlinson
Dec 11, 2020·Neurology. Clinical Practice·Lydia MarcusJayne Ness
Mar 13, 2021·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Stefano FontanaPaola Stefanelli
Jun 8, 2021·The Pediatric Infectious Disease Journal·Núria WörnerCarlos Rodrigo

❮ Previous
Next ❯

Related Concepts

Related Feeds

Ataxias

Ataxia is a neurological condition characterized by lack of voluntary coordination of muscle movements including loss of coordination, balance, and speech. Discover the latest research on different types of ataxias here.

Ataxias (MDS)

Ataxia is a neurological condition characterized by lack of voluntary coordination of muscle movements including loss of coordination, balance, and speech. Discover the latest research on ataxia here.

Ataxia

Ataxia is a neurological condition characterized by lack of voluntary coordination of muscle movements including loss of coordination, balance, and speech. Discover the latest research on ataxia here.

CSF & Lymphatic System

This feed focuses on Cerebral Spinal Fluid (CSF) and the lymphatic system. Discover the latest papers using imaging techniques to track CSF outflow into the lymphatic system in animal models.

Related Papers

Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America
P McMinnS Davis
Pediatrics and Neonatology
Shih-Min WangChing-Chuan Liu
Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia
Kyung Yeon LeeSang-Ook Nam
© 2022 Meta ULC. All rights reserved