Clinical Characteristics and Immune Injury Mechanisms in 71 Patients with COVID-19.

MSphere
Yingjie WuQiuping Zhang

Abstract

The outbreak of coronavirus disease 2019 (COVID-19), caused by the novel coronavirus severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has caused a threat to global health. The mortality rate of severely ill patients in the early stage is 32.5%. The exacerbation of the condition and death of patients are closely associated with inflammatory cytokine storms, which are caused by excessive activation of the immune and complement systems as well as the coinfection of other pathogens. However, the immunological characteristics and the mechanisms underlying inflammatory storms have not been well elucidated. Here, we analyzed the clinical and immunological characteristics of 71 confirmed COVID-19 patients. Based on the National Health Commission of China (NHCC) guidelines, patients were stratified into mild and severe types. We compared the clinical and laboratory data obtained from electronic medical records between the two types. In regard to the hematological parameters, COVID-19 patients showed decreased erythrocyte count, hemoglobin, hematocrit, lymphocyte count, eosinophil count, and complement C1q, whereas neutrophils, C-reactive protein, and procalcitonin were significantly increased, especially in severe cases. We...Continue Reading

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Citations

Jan 7, 2021·Trends in Immunology·Liriye Kurtovic, James G Beeson
Mar 12, 2021·Expert Review of Clinical Pharmacology·Sayeeda RahmanFrank Kunik
Jun 3, 2021·International Journal of Laboratory Hematology·Daniel Alberto Girón-PérezManuel Iván Girón-Pérez
Jul 15, 2021·Reviews in Medical Virology·Kun LiuWei Liu
Jul 15, 2021·ACS Chemical Neuroscience·Vitalakumar DS J S Flora

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Methods Mentioned

BETA
reverse transcription-PCR
fluorescence-activated cell sorting
flow cytometry

Software Mentioned

GraphPad Prism

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