Clinical characteristics and long term prognosis in early onset multiple sclerosis

Journal of Neurology
Olivier DeryckBénédicte Dubois

Abstract

The clinical features, disease course and long term prognosis of early onset multiple sclerosis (EOMS) are variable. A preponderance of female sex, a high incidence of visual and brainstem symptoms at onset and a relapsing-remitting disease course with slower progression rate all have been considered relatively frequent in this subgroup of MS patients. Unfortunately, follow-up in previous studies has usually been limited to less than 10 years, precluding general statements on the long term evolution and prognosis in EOMS. In this retrospective study of EOMS with a substantially longer follow-up of 20.8 years, clinical characteristics, disease course and long term prognosis are described in 49 EOMS patients. In a representative subgroup of 28 patients disability was scored using Kurtzke's Functional System (FS) and Expanded Disability Status Scale (EDSS). The mean period of follow- up for these patients was 28.7 years. The present study confirms that several specific clinical characteristics can be identified in EOMS patients, such as a mainly relapsing-remitting disease onset and frequent presentation with brainstem- cerebellar dysfunction (28.6 %), pyramidal symptoms (18.4 %) and optic neuritis (14.3%). However, after a long p...Continue Reading

References

Sep 1, 1992·Acta Neurologica Scandinavica·E SindernU Wurster
Sep 1, 1987·The Journal of Pediatrics·P DuquetteW Hader
Mar 1, 1983·Annals of Neurology·C M PoserW W Tourtellotte
Oct 1, 1994·Journal of Neurology·B RunmarkerO Andersen
Mar 1, 1995·Journal of Neurology, Neurosurgery, and Psychiatry·M TrojanoP Livrea
Jan 1, 1994·Annals of Neurology·B G Weinshenker
Jan 1, 1996·European Neurology·D SelcenY Renda
Feb 1, 1997·Multiple Sclerosis : Clinical and Laboratory Research·A GhezziM Zaffaroni
Aug 17, 1999·Neurology·M RuggieriL M Grimaldi
Jun 10, 2000·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·S R HammondD R English
Jan 18, 2002·The New England Journal of Medicine·Peter A BrexDavid H Miller
Mar 26, 2002·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·E VerdunUNKNOWN Betaferon Safety Trial (BEST) Study Group
May 7, 2002·Multiple Sclerosis : Clinical and Laboratory Research·A GhezziM Zaffaroni
Mar 5, 2003·Brain : a Journal of Neurology·Christian ConfavreuxPatrice Adeleine

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Citations

Oct 15, 2009·Nature Reviews. Neurology·E Ann YehUNKNOWN US Network of Pediatric Multiple Sclerosis Centers of Excellence
Jan 13, 2011·Nature Reviews. Neurology·Brenda BanwellMarc Tardieu
Mar 12, 2010·The Neurologist·Sunita Venkateswaran, Brenda Banwell
Oct 1, 2011·Topics in Magnetic Resonance Imaging : TMRI·Antonio José da RochaAntonio Carlos Martins Maia
Feb 26, 2010·Annals of Indian Academy of Neurology·Yashma PatelLauren Krupp
Dec 3, 2013·Autoimmune Diseases·Joaquin A Pena, Timothy E Lotze
Dec 3, 2014·Neurologic Clinics·Leticia TornesWilliam Sheremata
Dec 2, 2010·Women's Health·Céline JobinPierre Duquette
Sep 14, 2014·Journal of the Neurological Sciences·Elhachmia Ait Ben HaddouMohamed Yahyaoui
Apr 24, 2013·Neuroimaging Clinics of North America·Leonard H VerheyBrenda Banwell
Jul 15, 2015·European Journal of Pediatrics·Silvia Dell'AvventoStefano Sotgiu
Jun 7, 2008·Clinical Neurology and Neurosurgery·Christel RenouxChristian Confavreux
Oct 16, 2015·Pediatric Neurology·Brynjar Thor GudbjornssonÓlafur Thorarensen
Apr 17, 2015·Multiple Sclerosis and Related Disorders·L A BensonT Chitnis
Dec 24, 2011·Autoimmune Diseases·Manuel J Amador-PatarroyoGladis Montoya-Ortiz
Sep 23, 2010·Multiple Sclerosis : Clinical and Laboratory Research·Byung Chan LimJong-Hee Chae
Oct 11, 2015·Multiple Sclerosis : Clinical and Laboratory Research·Saeed AkhtarJasem Y Al-Hashel
Mar 11, 2018·BMC Neurology·Raed Alroughani, Alexey Boyko
Nov 20, 2016·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·R M van der Vuurst de VriesR Q Hintzen
May 4, 2021·JAMA Neurology·Damiano BaronciniUNKNOWN Italian MS registry

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