Abstract
Several previous studies have addressed the association between hepatitis C virus (HCV) infection and non-Hodgkin lymphoma (NHL), but there are few studies on HCV-related diffuse large B-cell lymphoma (DLBL). We conducted this retrospective study to investigate the distinctive clinical characteristics and outcome for HCV-positive DLBL. We compared the clinical characteristics and outcomes of 32 HCV-positive DLBL cases from nine Korean institutions with those of 371 HCV-negative DLBL cases. A higher percentage of HCV-positive DLBL cases were associated with old age (> or = 60) than HCV-negative DLBL cases at diagnosis (59.4% vs. 36.1%, respectively, P = 0.009) and HCV-positive cases were less likely than HCV-negative cases to have extranodal involvement (53.1% vs. 71.1%, respectively, P = 0.044). The nodal presentation was the only independent factor favorably influencing the event free survival (EFS) in HCV-positive DLBL (HR = 0.11, 95% CI; 0.01-0.95, P = 0.012). In comparison to patients with HCV-negative DLBL, HCV-positive DLBL patients had a superior complete response rate (P = 0.023) and EFS (P = 0.02). In Korean patients, HCV-positive DLBL is more common with old age and has less extranodal involvement than does HCV-negati...Continue Reading
References
Oct 29, 1993·Biochemical and Biophysical Research Communications·S H ChoY I Lee
Sep 1, 1996·British Journal of Haematology·C MazzaroG Pozzato
Jul 8, 1998·Annals of Oncology : Official Journal of the European Society for Medical Oncology·M LuppiG Torelli
Nov 24, 1999·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·B D ChesonG P Canellos
Jan 8, 2000·The New England Journal of Medicine·E L MurphyA E Williams
Dec 12, 2001·Blood·E R QuinnS Levy
Aug 3, 2002·Leukemia & Lymphoma·Daniela GasparottoMauro Boiocchi
Jan 15, 2003·Journal of Virology·Vicky M-H SungMichael M C Lai
Jan 16, 2004·Gastroenterology·Javier P GisbertRicardo Moreno-Otero
Apr 13, 2004·European Journal of Gastroenterology & Hepatology·Javier P GisbertRicardo Moreno-Otero
Jun 9, 2004·International Journal of Cancer. Journal International Du Cancer·Eva NegriSilvia Franceschi
Oct 9, 2004·Cancer Science·Keitaro MatsuoNancy E Mueller
Mar 16, 2005·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Jens ReimerMichael Krausz
Mar 18, 2005·Alimentary Pharmacology & Therapeutics·J P GisbertR Moreno-Otero
Mar 25, 2005·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·C MazzaroG Pozzato
Sep 17, 2005·Intervirology·Hai-Rim Shin
Jan 19, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Caroline BessonUNKNOWN Groupe d'Etude des Lymphomes de l'Adulte Programs
Feb 24, 2006·Blood·Luca ArcainiUNKNOWN Integruppo Italiano Linfomi
Jun 13, 2006·Annals of Oncology : Official Journal of the European Society for Medical Oncology·C ViscoF Rodeghiero
Nov 8, 2006·Gastroenterology·Alexandra NietersSilvia De Sanjosé
Nov 23, 2006·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Luigino Dal Maso, Silvia Franceschi
Jan 20, 2007·British Journal of Haematology·Luca ArcainiUNKNOWN Intergruppo Italiano Linfomi
Citations
Jan 1, 2011·Revista brasileira de hematologia e hemoterapia·Michelle Maccarini Barcelos, Maria Cláudia Santos-Silva
Feb 12, 2014·Leukemia & Lymphoma·Cristhiam M Rojas-HernandezM Houman Fekrazad
Jan 21, 2010·The American Journal of the Medical Sciences·Brian C KellerJonathan E Dowell
Sep 21, 2010·Cytometry. Part B, Clinical Cytometry·Claudia FaziPaolo Ghia
Nov 25, 2014·American Journal of Hematology·Jean-Marie MichotUNKNOWN ANRS HC-13 Lympho-C Study Group
Apr 23, 2015·Cancer Epidemiology·Yi-Yang ChenChih-Cheng Chen
Jul 7, 2011·Clinical Lymphoma, Myeloma & Leukemia·Ajay NookaChristopher R Flowers
Dec 3, 2014·Critical Reviews in Oncology/hematology·Semra Paydas
Apr 8, 2016·Therapeutic Advances in Hematology·Barbara VannataEmanuele Zucca
Jul 12, 2012·The Korean Journal of Hematology·Jooryung Huh
Aug 30, 2014·World Journal of Gastroenterology : WJG·Carlo Visco, Silvia Finotto
Feb 14, 2020·Clinical and Experimental Medicine·Irene DefrancescoLuca Arcaini
Feb 9, 2018·Oncotarget·Joji ShimonoKoichi Ohshima
Nov 14, 2018·British Journal of Biomedical Science·I SghaierB Y Loueslati
Dec 17, 2017·Annals of Hematology·Xiang ZhouMathias Witzens-Harig
Feb 8, 2019·Annals of Hematology·Joji ShimonoKoichi Ohshima
May 12, 2020·Current Cancer Drug Targets·Tamer A ElbedewyMarwa A Suliman
Oct 11, 2021·Cancer Cell International·Minyue ZhangHonghui Huang