Clinical characteristics and outcomes of HIV-associated immune complex kidney disease

Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association
John W BoothHIV/CKD Study and the UK CHIC Study

Abstract

The pathogenesis and natural history of HIV-associated immune complex kidney disease (HIVICK) is not well understood. Key questions remain unanswered, including the role of HIV infection and replication in disease development and the efficacy of antiretroviral therapy (ART) in the prevention and treatment of disease. In this multicentre study, we describe the renal pathology of HIVICK and compare the clinical characteristics of patients with HIVICK with those with IgA nephropathy and HIV-associated nephropathy (HIVAN). Poisson regression models were used to identify risk factors for each of these pathologies. Between 1998 and 2012, 65 patients were diagnosed with HIVICK, 27 with IgA nephropathy and 70 with HIVAN. Black ethnicity and HIV RNA were associated with HIVICK, receipt of ART with IgA nephropathy and black ethnicity and CD4 cell count with HIVAN. HIVICK was associated with lower rates of progression to end-stage kidney disease compared with HIVAN and IgA nephropathy (P < 0.0001). Patients with HIVICK who initiated ART and achieved suppression of HIV RNA experienced improvements in estimated glomerular filtration rate and proteinuria. These findings suggest a pathogenic role for HIV replication in the development of HIVI...Continue Reading

References

Sep 3, 1992·The New England Journal of Medicine·P L KimmelC T Garrett
Dec 1, 1993·Kidney International·P L KimmelC T Garrett
Aug 26, 2004·Kidney International·Lynda Anne SzczechJonathan A Winston
Apr 21, 2006·Kidney International·T E GerntholtzI Katz
May 1, 2008·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Frank A PostPhilippa J Easterbrook
Nov 18, 2008·Seminars in Nephrology·Scott D Cohen, Paul L Kimmel
Jul 13, 2011·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Naïke BigéGuillaume Bollée
Nov 29, 2011·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Fowzia IbrahimUNKNOWN UK CHIC/CKD* Study Group
Dec 28, 2011·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Nicola WearneBrian L Rayner
Feb 28, 2013·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·June FabianWillem Daniel Francois Venter
May 21, 2013·Clinical Journal of the American Society of Nephrology : CJASN·Matthew C FoyMohamed G Atta
Dec 7, 2013·Journal of the American Society of Nephrology : JASN·Guillaume CanaudChristophe Legendre
Jun 1, 2012·Kidney International Supplements
Sep 23, 2014·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Gregory M LucasUNKNOWN HIV Medicine Association of the Infectious Diseases Society of America

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Citations

Jan 18, 2018·Current Opinion in Nephrology and Hypertension·Jean Hou, Cynthia C Nast
Dec 14, 2017·The New England Journal of Medicine·Scott D CohenPaul L Kimmel
Jan 19, 2018·International Journal of STD & AIDS·Joana GameiroJosé A Lopes
Jul 10, 2018·The Journal of Infectious Diseases·Sophie JoseUNKNOWN UK CHIC Study
Nov 1, 2016·Clinical Journal of the American Society of Nephrology : CJASN·Warren L Kupin
Apr 2, 2019·AIDS·Nicola WearneFrank A Post
Sep 29, 2020·Clinical Case Reports·Mark TiongAnastasia Chrysostomou
Dec 21, 2016·Clinical Kidney Journal·Pedro CamposKarina Soto
Nov 10, 2018·HIV Medicine·J GameiroJ A Lopes
Sep 20, 2020·BMC Nephrology·Vivek CharuNeeraja Kambham
Aug 23, 2019·Journal of Clinical Medicine·Gaetano AlfanoGiovanni Guaraldi
Mar 18, 2020·AIDS Research and Therapy·Jack Edward HeronDavid M Gracey
Sep 22, 2020·Expert Opinion on Pharmacotherapy·Anam TariqMohamed G Atta
Feb 23, 2021·KI Reports·Sanjeev SethiFernando C Fervenza
Jun 12, 2021·International Journal of Nephrology and Renovascular Disease·Sheena PramodZeid Khitan
Jul 22, 2021·EClinicalMedicine·Rachel K Y HungUNKNOWN GEN-AFRICA study group

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