Clinical characteristics and outcomes of lung cancer patients with combined pulmonary fibrosis and emphysema: a systematic review and meta-analysis of 13 studies

Journal of Thoracic Disease
Chuan LiLunxu Liu

Abstract

The characteristic and outcomes of lung cancer patients with combined pulmonary fibrosis and emphysema (CPFE) have long been assessed, but results were controversial. Therefore, we performed a meta-analysis to assess the clinical features and prognosis of lung cancer patients with CPFE. The databases PubMed, Embase, and Web of Science (updated to October 1, 2017) were searched for eligible studies. Pooled odds ratios (ORs), weighted mean differences (WMD) or hazard ratios (HRs) with 95% confidence intervals (95% CIs) were used to evaluate the clinicopathological characteristics, the short-term outcome after operation and long-term survival of lung cancer patients with CPFE compared with lung cancer patients without CPFE (fibrosis, emphysema, and normal). Thirty original studies with 8,050 patients were included in this meta-analysis. The pooled results indicated that lung cancer patients with CPFE were associated with higher age (MD =3.39; 95% CI: 2.12-4.67, P<0.001), male (OR =8.46; 95% CI: 6.36-11.26, P<0.001), ex- or current smoker (OR =39.65; 95% CI: 15.64-100.5, P<0.001), longer smoking history (MD =15.56; 95% CI: 3.73-27.39, P=0.01), lower DLCO% (MD =-13.82; 95% CI: -21.4 to -6.24, P<0.001), squamous cell carcinoma histol...Continue Reading

Citations

Sep 27, 2019·Frontiers in Oncology·Lorena GiurannoMarc A Vooijs
Aug 30, 2019·Lung India : Official Organ of Indian Chest Society·Irfan Ismail Ayub, Natraj Manimaran
Jan 16, 2021·Cancer radiothérapie : journal de la Société française de radiothérapie oncologique·J-H YuX-W Cai
Feb 5, 2021·International Journal of Chronic Obstructive Pulmonary Disease·René HageMacé M Schuurmans
Sep 16, 2021·Internal and Emergency Medicine·Loredana CarobenePaola Rottoli

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