Clinical characteristics and prognosis of patients with hepatoblastoma

World Journal of Surgery
S E JungW K Kim

Abstract

Hepatoblastoma is a rare pediatric malignancy that frequently appears in an advanced unresectable stage. Improved resectability and survival rate have been reported with the help of neoadjuvant chemotherapy. Between January 1987 and June 1995 a series of 20 patients were managed with a diagnosis of hepatoblastoma. The median age at diagnosis was 13 months (2 months to 7 years 10 months) with a male/female ratio of 13:7. Chemotherapy effectively reduced the tumor volume (with statistical significance: p = 0.008) and was able to convert seven of nine initially unresectable tumors (78%) to resectable ones. Altogether, 14 operations were done, 12 radical and 2 palliative, with or without adjuvant chemotherapy. The whole population was followed for a median duration of 33 months; and the median survival for the whole group was 26 months. The curative resection group displayed a 5-year survival rate of 61.1%, but none in the noncurative group survived more than 13 months (p = 0.0001). In the univariate analysis for prognostic factors, large tumor size at diagnosis and the absence of thrombocytopenia were associated with poor survival, but these differences were not statistically significant. Pure fetal histology was not associated wi...Continue Reading

Citations

Dec 22, 2005·World Journal of Surgery·Seung-Beom YuWoo-Ki Kim
Mar 4, 2011·Pediatric Blood & Cancer·Kyung Nam KohJong Jin Seo
Jul 12, 2011·Pediatric Blood & Cancer·Angela D Trobaugh-LotrarioJames H Feusner
May 12, 2004·Journal of Pediatric Surgery·Bryan J DickenGordon M Lees

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