Clinical Characteristics and Prognostic Significance of TERT Promoter Mutations in Cancer: A Cohort Study and a Meta-Analysis

PloS One
Ping YuanJian Hu

Abstract

The prevalence of telomerase reverse transcriptase (TERT) promoter mutations (pTERTm) in non-small-cell lung cancer (NSCLC) have been investigated, but the results were inconsistent. In addition, several studies have analysed the role of pTERTm in the etiology of various types of cancers, however, the results also remain inconsistent. The genomic DNA sequence of 103 NSCLC samples were analysed to investigate the frequency of pTERTm in these patients and to establish whether these mutations are associated with their clinical data. Furthermore, a meta-analysis based on previously published articles and our cohort study was performed to investigate the association of pTERTm with patient gender, age at diagnosis, metastasis status, tumour stage and cancer prognosis (5-year overall survival rate). In the cohort study, 4 patients had C228T and 2 had C250T, with a total mutation frequency up to 5.8%. Significant difference of clinical data between pTERTm carriers and noncarriers was only found in age at diagnosis. In the meta-analysis, We found that pTERTm carriers in cancer patients are older than noncarriers (Mean difference (MD) = 5.24; 95% confidence interval [CI], 2.00 to 8.48), male patients were more likely to harbour pTERTm (o...Continue Reading

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Citations

May 13, 2018·Genes·Tiago Bordeira GasparJoão Vinagre
Feb 9, 2018·Oncotarget·Lingling WangXichuan Li
Feb 10, 2018·Oncotarget·Haihua RuanXichuan Li
Mar 13, 2018·Journal of Biomedical Science·Ricardo LeãoPedro Castelo-Branco
Feb 7, 2021·Journal of Cancer Research and Clinical Oncology·Branka PowterTherese M Becker

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Methods Mentioned

BETA
surgical resection
electrophoresis
PCR

Software Mentioned

Review Manager ( revman )
STATA
SPSS16
pTERTm
Engauge Digitizer

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