Clinical characteristics and survival outcomes of super-elderly hepatocellular carcinoma patients not indicated for surgical resection

Hepatology Research : the Official Journal of the Japan Society of Hepatology
Akiyoshi KinoshitaHisao Tajiri

Abstract

Considering the dramatic increase in average life expectancy during the 20th century throughout the world, the management of elderly patients with cancer has become a global issue. We herein investigated the clinical characteristics and outcomes of super-elderly hepatocellular carcinoma (HCC) patients over 80 years old not indicated for surgical resection. We retrospectively evaluated 206 newly diagnosed HCC patients. The patients were divided into two groups according to their age at inclusion; a super-elderly group (n = 37, ≥80 years) and a younger group (n = 169, <80 years). We compared the clinical characteristics, overall survival (OS) and disease-specific survival (DSS) rates among the two groups. Both univariate and multivariate analyses were performed to identify the factors associated with the OS and DSS. The proportion of women was higher in the super-elderly group than in the younger group (P = 0.017). There were no significant differences in the OS (P = 0.171) or DSS (P = 0.176) between the two groups. The multivariate analysis revealed that only the Cancer Liver Italian Program score (hazard ratio [HR], 2.972; P < 0.0001; HR, 3.694; P < 0.0001) was independently associated with the OS and DSS. Age was not found to ...Continue Reading

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Feb 6, 2016·Geriatrics & Gerontology International·Akiyoshi KinoshitaHirokazu Nishino
Oct 7, 2021·Asian Journal of Endoscopic Surgery·Shigetoshi NaitoSuguru Hasegawa

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