Clinical characteristics by topographical distribution of brain microbleeds, with a particular emphasis on diffuse microbleeds

Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association
Yusuke YakushijiKazuo Minematsu

Abstract

From the perspective of the underlying pathogenesis of primary intracerebral hemorrhage (pICH), the topographical distribution of brain microbleeds (MBs) is divided into the lobar area and the deep brain or infratentorial areas. We investigated clinical features, including ambulatory blood pressure (ABP), of patients with MBs distributed in both areas (diffuse MBs). A total of 124 patients with first-ever acute stroke were enrolled prospectively. Gradient-echo T2∗-weighted magnetic resonance imaging (MRI) was performed using a 1.5-T scanner. Patients were classified into 4 groups: MBs-negative group (n=68), those with MBs in lobar areas (lobar group; n=6), those with MBs in deep or infratentorial areas (deep or infratentorial group; n=31), and those with MBs in both areas (diffuse group; n=19). The admission casual BP (CBP) was recorded in all patients, and ABP was measured in the ischemic stroke patients. There were significant differences in the distribution of MBs (P=.004) among the 6 stroke subtypes. All stroke subtypes except transient ischemic attack had diffuse MBs; pICH had the highest prevalence of it (35%). The severity of white matter hyperintensity (WMH) differed among the 4 groups (P < .0001), with the diffuse grou...Continue Reading

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Citations

Sep 2, 2014·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Junpei NagasawaKen Ikeda
Sep 25, 2012·European Journal of Internal Medicine·Ryo ItabashiNaoaki Yamada
May 23, 2012·Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging·David S LiebeskindJeffrey L Saver
Jan 15, 2013·Journal of the Neurological Sciences·Michiya IgaseTetsuro Miki
Jun 2, 2016·Annals of Nuclear Medicine·Tetsuya HashimotoKazunori Toyoda
Oct 1, 2016·AJNR. American Journal of Neuroradiology·I BarnaureS Haller
Mar 21, 2018·Radiology·Sven HallerFrederik Barkhof
May 15, 2012·Stroke; a Journal of Cerebral Circulation·Yusuke YakushijiHideo Hara
Feb 14, 2014·Annals of African Medicine·Imarhiagbe Frank Aiwansoba, Ordia Wallace Chukwuyem
Jan 6, 2017·Alzheimer's & Dementia : Diagnosis, Assessment & Disease Monitoring·Mekala R RamanPrashanthi Vemuri
Nov 12, 2019·Frontiers in Neurology·Clemence BlancNicolas Raposo
Mar 17, 2019·International Journal of Molecular Sciences·Maria Del C Valdés HernándezJoanna M Wardlaw
Feb 6, 2020·Journal of Neurology·Muneaki KikunoUNKNOWN CHALLENGE ESUS/C.S. collaborators
May 24, 2014·Expert Review of Neurotherapeutics·Duncan WilsonDavid J Werring
Jun 28, 2021·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Min Jae MyungJin San Lee

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