Clinical characteristics, laboratory findings, radiographic signs and outcomes of 61,742 patients with confirmed COVID-19 infection: A systematic review and meta-analysis

Microbial Pathogenesis
Ali PormohammadNathan C Bahr

Abstract

In the current time where we face a COVID-19 pandemic, there is no vaccine or effective treatment at this time. Therefore, the prevention of COVID-19 and the rapid diagnosis of infected patients is crucial. We searched all relevant literature published up to February 28, 2020. We used Random-effect models to analyze the appropriateness of the pooled results. Eighty studies were included in the meta-analysis, including 61,742 patients with confirmed COVID-19 infection. 62.5% (95% CI 54.5-79, p < 0.001) of patients had a history of recent travel endemic area or contact with them. The most common symptoms among COVID-19 infected patients were fever 87% (95% CI 73-93, p < 0.001), and cough 68% (95% CI 55.5-74, p < 0.001)), respectively. The laboratory analysis showed that thrombocytosis was present in 61% (95% CI 41-78, p < 0.001) CRP was elevated in 79% (95% CI 65-91, p < 0.001), and lymphopenia in 57.5% (95% CI 42-79, p < 0.001). The most common radiographic signs were bilateral involvement in 81% (95% CI 62.5-87, p < 0.001), consolidation in 73.5% (95% CI 50.5-91, p < 0.001), and ground-glass opacity 73.5% (95% CI 40-90, p < 0.001) of patients. Case fatality rate (CFR) in <15 years old was 0.6%, in >50 years old was 39.5%, and i...Continue Reading

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Citations

May 27, 2020·Journal of Cellular Physiology·Safa TahmasebiAbdolreza Esmaeilzadeh
May 22, 2019·Journal of the American Podiatric Medical Association·Alexis ZavisanosAndrew J Meyr
Feb 6, 2021·Hormone Molecular Biology and Clinical Investigation·Swanjal BansodSmita R Sorte
Oct 30, 2020·International Journal of Molecular Sciences·Jan BrábekKarel Smetana
Mar 18, 2021·Annals of Clinical Microbiology and Antimicrobials·Erfan KazemiHossein Sheibani
Mar 21, 2021·Molecular and Cellular Biochemistry·Ling-Zhi HongXue Jin
Jul 1, 2020·Epidemiology and Infection·Malahat KhaliliHamid Sharifi
Apr 6, 2021·Journal of Taibah University Medical Sciences·Rania M FelembanDoaa K Mohorjy
Jun 10, 2020·Intensive Care Medicine·Shadman AzizMichael D Christian
Jun 4, 2021·JMIR Public Health and Surveillance·Rami QaisiehAlmothana Hamdan
Sep 22, 2021·Signal Transduction and Targeted Therapy·Hao DengLamei Yuan

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Methods Mentioned

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PCR
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EndNote
Comprehensive Meta - Analysis
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