Clinical Characteristics of Aldosterone- and Cortisol-Coproducing Adrenal Adenoma in Primary Aldosteronism

International Journal of Endocrinology
Lu TangXu Zhang

Abstract

Aldosterone- and cortisol-coproducing adrenal adenoma (A/CPA) cases have been observed in patients with primary aldosteronism (PA). This study investigated the incidence, clinical characteristics, and molecular biological features of patients with A/CPAs. We retrospectively identified 22 A/CPA patients from 555 PA patients who visited the Chinese People's Liberation Army General Hospital between 2004 and 2015. Analysis of clinical parameters revealed that patients with A/CPAs had larger tumors than those with pure APAs (P < 0.05). Moreover, they had higher proportions of cardiovascular complications, glucose intolerance/diabetes, and osteopenia/osteoporosis compared to the pure APA patients (P < 0.001). In the molecular biological findings, quantitative real-time PCR analysis revealed similar CYP11B1 and CYP17A1 mRNA expressions in resected A/CPA specimens and in pure APA specimens. Western blot and immunochemical analyses showed CYP11B1, CYP11B2, and CYP17A1 expressions in both A/CPAs and pure APAs. Seventeen cases with KCNJ5 mutations were detected among the 22 A/CPA DNA samples, but no PRKACA or other causative mutations were observed. Each patient improved following adrenalectomy. In conclusion, A/CPAs were not rare among P...Continue Reading

References

Sep 1, 1992·The Journal of Clinical Endocrinology and Metabolism·M ReinckeW Winkelmann
Mar 1, 1991·The Journal of Clinical Endocrinology and Metabolism·T ImaiH Takagi
May 1, 1993·Clinical and Experimental Pharmacology & Physiology·M StowasserR D Gordon
Apr 19, 2000·The Journal of Clinical Endocrinology and Metabolism·R RossiG Lombardi
May 24, 2000·Journal of Human Hypertension·P O LimT M MacDonald
Jan 5, 2002·Hypertension Research : Official Journal of the Japanese Society of Hypertension·T HondaM Kurabayashi
Nov 5, 2002·The Journal of Clinical Endocrinology and Metabolism·Libuse TauchmanovàGaetano Lombardi
Jun 11, 2003·Hypertension·Lorena MossoCarlos E Fardella
Aug 20, 2003·Internal Medicine·Junji AdachiHironobu Sasano
Oct 22, 2003·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Akira SugawaraSadayoshi Ito
Apr 15, 2004·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Masao OmuraTetsuo Nishikawa
Apr 20, 2005·Journal of the American College of Cardiology·Paul MilliezJean-Jacques Mourad
Apr 30, 2005·The Journal of Steroid Biochemistry and Molecular Biology·John W Funder
Jun 9, 2005·The Journal of Clinical Endocrinology and Metabolism·Michael StowasserThomas H Marwick
Jul 8, 2005·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·A WolfW T Knoefel
Mar 10, 2007·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Masao OmuraTetsuo Nishikawa
Jun 2, 2007·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Jiro SuzukiHirofumi Makino
Jan 16, 2008·Archives of Internal Medicine·Cristiana CatenaLeonardo A Sechi
Jun 17, 2008·The Journal of Clinical Endocrinology and Metabolism·John W FunderUNKNOWN Endocrine Society
Feb 5, 2009·The Journal of Clinical Endocrinology and Metabolism·E Born-FrontsbergUNKNOWN Participants of the German Conn's Registry
Feb 20, 2009·Clinical Endocrinology·Georgios P PiaditisGeorgios Chrousos
Jun 9, 2009·Best Practice & Research. Clinical Endocrinology & Metabolism·Massimo TerzoloAlberto Angeli
Jun 11, 2009·Clinical Endocrinology·Francesco Fallo, Nicoletta Sonino
Jan 29, 2011·European Journal of Endocrinology·Martin SpäthHolger S Willenberg
May 20, 2011·The Journal of Clinical Endocrinology and Metabolism·Yasuyo NakajimaMasatomo Mori
Nov 11, 2011·International Journal of Surgical Pathology·Valentina VicennatiRenato Pasquali
Jan 26, 2012·Hypertension·Sheerazed BoulkrounMaria-Christina Zennaro
May 26, 2012·The Journal of Clinical Endocrinology and Metabolism·Silvia MonticoneWilliam E Rainey
Aug 7, 2012·Endocrine Journal·Masanobu YamadaMasatomo Mori
Aug 6, 2013·Nature Genetics·Elena A B AzizanMorris J Brown
Apr 22, 2014·Nature Genetics·Gerald GohRichard P Lifton
Sep 23, 2014·The Journal of Clinical Endocrinology and Metabolism·Miguel DebonoJohn Newell-Price
Dec 30, 2014·European Journal of Endocrinology·George PiaditisGregory Kaltsas

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Citations

Aug 14, 2020·The Journal of Clinical Endocrinology and Metabolism·Samuel Matthew O'TooleWilliam Martyn Drake
Oct 27, 2020·Frontiers in Endocrinology·Shaomin ShiTao Chen
May 29, 2021·Frontiers in Endocrinology·Shamaila ZamanFlorian Wernig

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Methods Mentioned

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PCR

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SPSS

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