Clinical characteristics of cognitive impairment in patients with Parkinson's disease and its related pattern in 18 F-FDG PET imaging

Human Brain Mapping
Lei WuJian Wang

Abstract

This study aimed to characterize the clinical features and the related cerebral glucose metabolism pattern of cognitive impairments in Parkinson's disease (PD) with positron emission tomography (PET) imaging. We recruited 168 PD patients and 100 age-matched healthy controls of similar education and gender distribution. All of those enrolled underwent clinical assessment including the unified Parkinson's disease rating scale motor score, Hoehn and Yahr scale, and comprehensive neuropsychological tests including domains of executive function, attention, memory, visuospatial function, and language. Demographics and the results of cognitive measures were compared between patients and healthy controls. Cognition status was classified as PD patients with dementia (PD-D), PD patients with mild cognitive impairment (PD-MCI), or PD patients with normal cognition (PD-NC). In 53 PD patients who underwent 18 F-fluorodeoxyglucose (18 F-FDG) PET imaging, correlations between Z-score values of the different cognitive domains and cerebral 18 F-FDG uptake were assessed using statistical parametric mapping (SPM8) corrected for age and motor severity. A total of 23.2% of PD patients were PD-MCI and 8.9% were PD-D. In the group of PD-MCI, 96.3% sh...Continue Reading

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Citations

Jun 18, 2019·Therapeutic Advances in Neurological Disorders·Yu-Jie YangJian Wang
Jul 26, 2019·European Journal of Nuclear Medicine and Molecular Imaging·Jenny CeccariniKoen Van Laere
Jan 30, 2021·European Journal of Nuclear Medicine and Molecular Imaging·Pietro MattioliDario Arnaldi
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Apr 20, 2021·Frontiers in Neurology·Cong ShenJian Wang
May 23, 2021·Movement Disorders : Official Journal of the Movement Disorder Society·Beatrice OrsoMatteo Pardini
Jul 27, 2021·Annals of Clinical and Translational Neurology·Hailing LiuQing Wang
Nov 30, 2021·Clinical Autonomic Research : Official Journal of the Clinical Autonomic Research Society·Sung Hoon KangSeong-Beom Koh

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