Clinical characteristics of cortical multiple sclerosis

Journal of the Neurological Sciences
M Zarei

Abstract

There are several articles in this special issue in which authors eloquently describe neurobehavioural and cognitive complications of multiple sclerosis with relevant neuropsychological assessments and neuroimaging findings. However behavioural and cognitive presentation of multiple sclerosis remains poorly understood. Two years ago, we reported a series of patients with multiple sclerosis who presented with neurobehavioural symptoms and had neuropsychological deficits consistent with cortical dysfunction. Based on previous case reports, pathological studies of cerebral cortex in multiple sclerosis and advanced neuroimaging studies we suggested that neurobehavioural presentation of multiple sclerosis represents a new variant called "cortical multiple sclerosis". The condition is characterised by predominant or exclusive cortical pathology presenting with neurobehavioural symptoms, such as depression, amnesia or distinct cortical syndromes. Since the publication of our report, there has been further neuroimaging and neuropathological findings that further supported the above concept. In addition, observation of more patients with this condition helped us to formulate a logical approach in the detection of these patients. This ar...Continue Reading

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Citations

Aug 16, 2008·Lancet Neurology·Jeroen J G Geurts, Frederik Barkhof
Mar 9, 2012·BMC Neurology·Dana HorakovaOndrej Dolezal
Mar 4, 2014·Multiple Sclerosis International·Silvia Messina, Francesco Patti
Dec 25, 2009·Clinical Neurology and Neurosurgery·Souraya Stoquart-ElsankariOlivier Godefroy
Mar 3, 2009·Journal of the Neurological Sciences·Jeroen J G GeurtsR Zivadinov
Jun 24, 2014·Journal of Neurology·Laura ParisiMassimo Filippi
Oct 23, 2016·BMC Neurology·Olivia GeisselerMichael Linnebank
Nov 30, 2014·Multiple Sclerosis : Clinical and Laboratory Research·Massimiliano CalabreseSalvatore Monaco
Sep 18, 2010·Multiple Sclerosis : Clinical and Laboratory Research·J A F CoeberghT C A M van Woerkom
Aug 12, 2009·Multiple Sclerosis : Clinical and Laboratory Research·M Calabrese, P Gallo
Mar 21, 2015·Multiple Sclerosis : Clinical and Laboratory Research·Marco PuthenparampilPaolo Gallo
Feb 13, 2014·Clinical Neuroradiology·S WeidauerE Hattingen

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