Clinical characteristics of impulse control and related disorders in Chinese Parkinson's disease patients

BMC Neurology
Yu ZhangZhen Guo Liu

Abstract

Impulse control and related disorders (ICRDs) are clinically complications in Parkinson's disease (PD). However, the clinical characteristics of ICRDs in Chinese PD patients were rarely reported. We aimed to explore the prevalence and the clinical profile of ICRDs in Chinese patients with PD. 142 Chinese PD patients were consecutively enrolled. The symptoms of ICRDs were assessed with the Questionnaire for Impulsive-Compulsive Disorders. The clinical characteristics of patients with ICRDs and without ICRDs were compared. ICRDs were present in 31% of our patients. The most common ICRDs were compulsive medication use (11.3%) and punding (9.2%); the least frequent were walkabout (1.4%). Variables independently associated with ICRDs were earlier onset of the disease (≤55 years), severe cognitive impairment (MMSE 10-20), the dose of dopamine agonist (>1 mg/d) and dyskinesia. ICRDs was commonly found in Chinese PD patients. Earlier onset of the disease, the dose of dopamine agonist, severe cognitive impairment and dyskinesia are independent factors associated with ICRDs. Our results will be benefit for clinicians to assess the risk of developing ICRDs before delivering dopaminergic medication.

References

Mar 29, 2000·Brain : a Journal of Neurology·G FénelonM Ziégler
May 20, 2009·Movement Disorders : Official Journal of the Movement Disorder Society·Daniel WeintraubValerie Voon
May 12, 2010·Archives of Neurology·Daniel WeintraubAnthony E Lang
Aug 16, 2011·Parkinsonism & Related Disorders·Shen-Yang LimPatrick Chin-Hooi Soh
Oct 11, 2011·Parkinsonism & Related Disorders·Juho JoutsaValtteri Kaasinen
Nov 1, 2011·Parkinsonism & Related Disorders·Iracema LeroiAlistair Burns
Jun 27, 2013·Movement Disorders : Official Journal of the Movement Disorder Society·Pournamy SarathchandranAsha Kishore
Nov 6, 2014·Movement Disorders : Official Journal of the Movement Disorder Society·Daniel WeintraubMark Stacy
Mar 12, 2015·Movement Disorders : Official Journal of the Movement Disorder Society·Chiara SiriGianni Pezzoli
Jul 1, 2015·Journal of the Neurological Sciences·Hamad Alzahrani, Annalena Venneri
Jul 29, 2015·Neuroscience and Biobehavioral Reviews·Haritz Jiménez-UrbietaMaría C Rodriguez-Oroz
Feb 24, 2017·Lancet Neurology·Valerie VoonPierre-Olivier Fernagut

❮ Previous
Next ❯

Citations

Jul 5, 2018·Arquivos de neuro-psiquiatria·Antonio Pedro Vargas, Francisco Eduardo Costa Cardoso
Dec 1, 2018·Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova·N N ShipilovaE A Katunina
Jul 30, 2019·Neurology. Neuroimmunology and Neuroinflammation·Michaël LevrautChristine Lebrun-Frenay
May 7, 2019·Frontiers in Neurology·Emilia M Gatto, Victoria Aldinio
Dec 24, 2019·Journal of Parkinson's Disease·Aaron Ben-JosephAlastair J Noyce
Jan 12, 2021·Movement Disorders Clinical Practice·Paloma Parra-DíazJuan Carlos Martínez-Castrillo
Aug 10, 2021·Journal of Neurology·Lanxiao CaoGuohua Zhao

❮ Previous
Next ❯

Software Mentioned

QUIP
SPSS

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.