Clinical characteristics of lupus enteritis in Japanese patients: the large intestine-dominant type has features of intestinal pseudo-obstruction

Lupus
A MaruyamaSeiji Minota

Abstract

This study was performed to investigate the clinical characteristics of lupus enteritis in Japanese patients with systemic lupus erythematosus (SLE). A total of 481 patients with SLE admitted to our hospital between 2001 and 2015 were retrospectively reviewed. Diagnosis of lupus enteritis was based on the following three criteria: (1) abdominal symptoms, (2) diffuse long-segment bowel thickening and (3) a requirement for glucocorticoid therapy. Lupus enteritis was identified in 17 patients (3.5%) and there were two distinct types: small intestine-dominant and large intestine-dominant. Significant differences between the two types were noted with respect to the age, frequency of biopsy-proven lupus nephritis, frequency of rectal involvement, maximum bowel wall thickness, and requirement for steroid pulse therapy. Among patients with large intestine-dominant lupus enteritis, 60% had extra-intestinal symptoms (hydroureter, bladder wall thickening, and bile duct dilatation) that are known complications of intestinal pseudo-obstruction. Two patients with large intestine-dominant lupus enteritis developed intestinal pseudo-obstruction either before or after diagnosis of lupus enteritis. Five patients (29%) developed recurrence during...Continue Reading

References

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Citations

Mar 14, 2019·Current Opinion in Gastroenterology·Martin KeuchelPeter Baltes
Aug 28, 2020·Current Rheumatology Reports·Estefania Calle-Botero, Andy Abril
Dec 5, 2020·Case Reports in Gastrointestinal Medicine·Akwe NyaberaAdriana Abrudescu
May 30, 2021·Rheumatology and Therapy·Hongxu WangWenxian You
May 24, 2021·Gastroenterología y hepatología·Marc Aparicio-RoviraAlejandro Olivé
Sep 28, 2021·Orphanet Journal of Rare Diseases·Long ChenFang He

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Methods Mentioned

BETA
X-ray

Software Mentioned

JMP Statistical Package

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