Clinical characteristics of male and female Korean patients with systemic lupus erythematosus: a comparative study

The Korean Journal of Internal Medicine
Jiwon HwangEun-Mi Koh

Abstract

To compare the clinical characteristics and outcomes of systemic lupus erythematosus between male and female Korean patients. A retrospective analysis was performed at a single tertiary hospital from August 1994 to May 2010. Male patients were matched with two to three female patients based on age and disease duration. Organ damage was assessed using the Systemic Lupus International Collaborating Clinics/American College of Rheumatology damage index (SLICC/ACR DI). Fifty-three male patients were compared with 150 female patients. Renal disorders were found more frequently in male patients at disease onset (p < 0.001); the adjusted odds ratio (OR) demonstrated a significant sex preponderance for renal manifestations (OR, 3.26; 95% confidence interval [CI], 1.62 to 6.57). Diffuse proliferative lupus nephritis and end-stage renal disease requiring dialysis during the disease course were more prevalent in male patients (p = 0.025 and p < 0.001, respectively). The risk for requiring long-term dialysis was significantly higher in male than in female patients (OR, 4.02; 95% CI, 1.07 to 15.06), as was the mean SLICC/ACR DI (1.55 ± 1.35 vs. 1.02 ± 1.57, respectively; p = 0.028). Our data demonstrate that Korean patients with lupus have ...Continue Reading

References

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Citations

May 12, 2017·The Korean Journal of Internal Medicine·Ju-Yang Jung, Chang-Hee Suh
Jan 5, 2018·International Urology and Nephrology·Wei PengWei Qin
Jun 20, 2018·Frontiers in Immunology·Kristy PurnamawatiChester Lee Drum
Dec 5, 2019·Frontiers in Cell and Developmental Biology·Rui-Juan ChengTony N Marion
Apr 1, 2021·Renal Failure·Hao-Yang MaYang Du
Aug 5, 2021·Nature Reviews. Rheumatology·Megan R W BarberRosalind Ramsey-Goldman

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Methods Mentioned

BETA
enzyme-linked immunosorbent assay
biopsy

Software Mentioned

SPSS
PASW

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