PMID: 24334571Dec 18, 2013Paper

Clinical characteristics of patients who developed hepatocellular carcinoma after hepatitis C virus eradication with interferon therapy: current status in Japan

Internal Medicine
Akira SatoTakafumi Ichida

Abstract

We attempted to elucidate the clinical features of chronic hepatitis C patients who develop hepatocellular carcinoma (HCC) after achieving a sustained viral response (SVR) to interferon (IFN) therapy. The clinical features of 130 patients at 19 hospitals who developed HCC after obtaining an SVR were retrospectively reviewed. Overall, 107 (82%) of the 130 patients were men, with 92 (71%) being ≥60 years of age and 76, 38 and 16 developing HCC within 5, 5-10 and 10-16.9 years after IFN therapy, respectively. Before receiving IFN therapy, 92 (71%) patients had cirrhosis and/or a low platelet count (<15×10(4) cells/μL). Lower albumin (<3.9 g/dL) and higher alpha fetoprotein (AFP) (≥10 ng/mL) levels were identified in a multivariate analysis to be independent variables of the development of HCC within five years after IFN therapy. Among 4,542 SVR patients, HCC occurred in 109 (2.4%) during a 5.5-year follow-up period, thus resulting in an occurrence rate of 4.6% for men and 0.6% for women. SVR patients with lower albumin or higher AFP levels require careful assessments to prevent early HCC development after IFN therapy. HCC occurrence within >10 years of IFN therapy is not uncommon, and the risk factors remain uncertain, thus sugges...Continue Reading

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Citations

Jul 24, 2014·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Naoki HiramatsuTetsuo Takehara
Jun 11, 2016·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Magnus HedenstiernaSoo Aleman
Feb 7, 2017·Gastroenterology·Kentaro MatsuuraUNKNOWN Japanese Genome-Wide Association Study Group for Viral Hepatitis
Apr 7, 2016·Revista Do Instituto De Medicina Tropical De São Paulo·Angelo Alves de MattosCristiane Valle Tovo
Jul 6, 2014·British Journal of Haematology·Caterina Borgna-PignattiStefano Volpato

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