Abstract
The clinical characteristics of patients with factor V Leiden or prothrombin G20210A presenting with a first episode of venous thromboembolism (VTE) have not been thoroughly studied. RIETE is an ongoing registry of consecutive patients with acute VTE. We compared the clinical characteristics of patients with factor V Leiden, prothrombin G20210A, or no thrombophilia, at presentation with a first episode of VTE. As of May 2009, 22428 patients had been enrolled with a first episode of VTE. Of these, 345 had factor V Leiden, 261 had prothrombin G20210A, and 2399 tested negative. Sixty-two percent of the VTE episodes in women with factor V Leiden or prothrombin G20210A (40% in men) were associated with an acquired risk factor. Among women, pregnancy or contraceptive use accounted for 63% and 67% of such risk factors. Patients with factor V Leiden presented with pulmonary embolism (PE) less likely than those with prothrombin G20210A (31% vs. 51%; p<0.001) or with negative testing (31% vs. 45%, p<0.001). In addition, PE patients with Factor V Leiden presented with hypoxaemia (Sat O(2) levels<90%) less likely than those with prothrombin G20210A (4.5% vs. 17%; p<0.001) or with no thrombophilia (4.5% vs. 20%; p<0.001). Most VTE episodes ...Continue Reading
References
Apr 1, 1991·American Journal of Hematology·M D TaberneroV Vicente
Nov 29, 1990·The New England Journal of Medicine·H HeijboerJ W ten Cate
Oct 1, 1993·American Journal of Hematology·A S AwidiB Anshasi
Aug 8, 1998·BMJ : British Medical Journal·T BaglinR Luddington
Nov 18, 2000·Chest·M MargaglioneG Di Minno
Jan 12, 2001·The American Journal of Medicine·G MeyerJ N Fiessinger
Apr 20, 2001·The New England Journal of Medicine·U Seligsohn, A Lubetsky
May 20, 2003·Acta Obstetricia Et Gynecologica Scandinavica·Pelle G Lindqvist, Björn Dahlbäck
Jul 23, 2003·Journal of Thrombosis and Haemostasis : JTH·I Martinelli
Nov 25, 2003·Journal of Thrombosis and Haemostasis : JTH·E A HellmannS Moll
Oct 26, 2005·Journal of Thrombosis and Haemostasis : JTH·I M van KorlaarA A Kaptein
Apr 6, 2006·Health Technology Assessment : HTA·O WuI Greer
Oct 28, 2006·Journal of Thrombosis and Haemostasis : JTH·I MartinelliP M Mannucci
Jul 26, 2007·Haematologica·Antonio MarchioriPaolo Prandoni
Oct 16, 2007·Current Opinion in Hematology·Olivia Wu, Ian A Greer
Nov 21, 2007·Hematology·John A Heit
May 10, 2008·Journal of Thrombosis and Haemostasis : JTH·D M CohnS Middeldorp
Jun 4, 2008·Thrombosis and Haemostasis·Elena RossiValerio De Stefano
Jul 10, 2008·Thrombosis and Haemostasis·Nuria Ruíz-GiménezUNKNOWN RIETE Investigators
Oct 22, 2008·Contraception·Verena GartnerSabine Eichinger
Dec 23, 2008·Thrombosis Research·Vanessa RoldanUNKNOWN RIETE Investigators
Jan 14, 2009·Blood·Willem M LijferingJan van der Meer
Jul 28, 2009·Journal of Thrombosis and Haemostasis : JTH·D AujeskyD Jiménez
Feb 4, 2010·Thrombosis and Haemostasis·A Blanco-MolinaUNKNOWN RIETE Investigators
Aug 13, 2011·Thrombosis and Haemostasis·Elena RossiValerio De Stefano
Citations
Nov 21, 2015·Thrombosis Research·Thomas DelateMargaret C Fang
Sep 11, 2012·Best Practice & Research. Clinical Haematology·Manuel MonrealEmmanouil Papadakis
Apr 26, 2013·Thrombosis and Haemostasis·Francesco DentaliDomenico Prisco
Feb 3, 2015·Translational Research : the Journal of Laboratory and Clinical Medicine·Joel FreedmanPing Wang
Feb 6, 2015·Applied Health Economics and Health Policy·C Rubio-TerrésE Salas
Mar 19, 2014·QJM : Monthly Journal of the Association of Physicians·J HirmerovaI Subrt
Feb 14, 2012·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·Francisco GabrielUNKNOWN RIETE Investigators
Dec 2, 2015·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·Charles J GlueckPing Wang
Mar 12, 2015·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·Georgia AnastasiouArgyri Gialeraki
Dec 24, 2018·Journal of Clinical Medicine·Charles J GlueckPing Wang