Clinical characteristics of patients with autoimmune hepatitis seropositive for anticentromere antibody

Hepatology Research : the Official Journal of the Japan Society of Hepatology
Takashi HimotoTsutomu Masaki

Abstract

Recent studies have revealed that primary biliary cirrhosis patients with anticentromere antibody (ACA) commonly develop portal hypertension. However, the clinical characteristics of autoimmune hepatitis (AIH) remain uncertain. We investigated the clinical features of patients with AIH seropositive for ACA (ACA-AIH), comparing them with those of patients with AIH seropositive for other immunofluorescent patterns of antinuclear antibodies (ANA) (other-AIH). AIH was diagnosed on the basis of the scoring system proposed by the International Autoimmune Hepatitis Group. Seropositivity for ACA was determined by a discrete speckled pattern on HEp-2 cells by an immunofluorescent technique. The severity of histological grading and staging was evaluated by the histological activity index (HAI) score. Eight (17%) of 47 patients with AIH had ACA. No significant differences in age, sex, onset pattern of the disease, progression to hepatic failure and relapse rate were present between the ACA-AIH and other-AIH groups. The frequency of concurrent autoimmune diseases in ACA-AIH was significantly higher than that in other-AIH (75% vs 36%, P = 0.0406). Biochemical analysis revealed a significantly lower mean immunoglobulin G (IgG) level than tha...Continue Reading

References

Feb 1, 1978·American Journal of Clinical Pathology·P I TerasakiY Iwaki
Jan 1, 1992·Internal Medicine·H YabeM Nagano
Dec 1, 1990·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·T SekiM Ota
Apr 1, 1987·The Journal of Cell Biology·W C EarnshawD W Cleveland
Jul 1, 1985·Journal of Clinical Pathology·F CassaniE Pisi
Jul 1, 1983·Arthritis and Rheumatism·D MakinenS Sherlock
Mar 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·Y MoroiE M Tan
Dec 1, 1982·Annals of the Rheumatic Diseases·R M BernsteinR Williams
Sep 1, 1981·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·R G KnodellJ Wollman
Sep 1, 1994·Clinical Rheumatology·M ZuberI Filler
Jan 1, 1993·Clinical Immunology and Immunopathology·I OutschoornI R Mackay
Mar 8, 2002·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Jun TojoReiji Kasukawa
Aug 4, 2004·Liver International : Official Journal of the International Association for the Study of the Liver·Albert J CzajaFrancesco B Bianchi
Dec 31, 2004·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Wei-Hong YangDonald B Bloch
Feb 1, 2005·Nihon Rinshō Men'eki Gakkai kaishi = Japanese journal of clinical immunology·Akiko AokiSyohei Nagaoka
Jan 6, 2006·The New England Journal of Medicine·Edward L Krawitt
Feb 1, 2006·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Michael P Manns, Arndt Vogel
Aug 31, 2006·Journal of Clinical Immunology·Branka Bonaci-NikolicMilos Nikolic
Sep 21, 2006·Journal of Gastroenterology and Hepatology·C E Eapen, I C Roberts-Thomson
Dec 26, 2006·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Minoru NakamuraHiromi Ishibashi
Mar 29, 2008·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Masaki IwaiYoshinori Harada
May 29, 2009·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·Y MiyakeK Yamamoto
Jul 28, 2009·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·Yasuhiro MiyakeKazuhide Yamamoto

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Citations

Apr 7, 2012·Clinics and Research in Hepatology and Gastroenterology·Catherine JohanetEric Ballot
Jan 1, 2013·Case Reports in Immunology·Moushumi LodhAshok Parida
Sep 16, 2014·Clinics and Research in Hepatology and Gastroenterology·Takashi HimotoTsutomu Masaki
Aug 1, 2013·Auto- Immunity Highlights·Takashi Himoto, Mikio Nishioka
Mar 27, 2018·Journal of Clinical and Translational Hepatology·Qi-Xia WangXiong Ma
Nov 10, 2020·Hepatology Communications·Craig LammertNaga Chalasani

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