Clinical Characteristics of Pediatric Optic Neuritis With Myelin Oligodendrocyte Glycoprotein Seropositive: A Cohort Study

Pediatric Neurology
Qian ChenGuohong Tian

Abstract

The clinical characteristics of patients with pediatric optic neuritis with seropositive myelin oligodendrocyte glycoprotein antibodies in Asia have not been reported. Patients ≤18 years-old with acute-onset optic neuritis were enrolled. Serum myelin oligodendrocyte glycoprotein and aquaporin-4 antibodies were detected and patients were followed for at least six months. The clinical features were evaluated among myelin oligodendrocyte glycoprotein-seropositive optic neuritis, aquaporin-4-seropositive optic neuritis, and double seronegative optic neuritis. Best-corrected visual acuity, thickness of optic disc retinal nerve fiber layer, and macular ganglion cell complex were measured by optical coherence tomography. Among myelin oligodendrocyte glycoprotein-optic neuritis, aquaporin-4-optic neuritis, and seronegative-optic neuritis, the percentages of best-corrected visual acuity measured better than 0.8 (20/25) at the six-month visit were 89.47%, 33.33%, and 82.26%, respectively, a rate that is significantly better in patients with myelin oligodendrocyte glycoprotein-optic neuritis and seronegative-optic neuritis (P = 0.02). The average peripapillary retinal nerve fiber layers were 58.03 ± 8.73 µm, 64.34 ± 12.88 µm, and 78.12 ± ...Continue Reading

Citations

Aug 23, 2019·Current Opinion in Ophthalmology·Jane H LockJason H Peragallo
Aug 1, 2020·Radiographics : a Review Publication of the Radiological Society of North America, Inc·Andres Server AlonsoPål B Marthinsen
Mar 4, 2020·Current Neurology and Neuroscience Reports·Ryan A Gise, Gena Heidary
Jul 17, 2020·Frontiers in Pediatrics·Silvia TenembaumUNKNOWN Guthy-Jackson Foundation International Clinical Consortium (GJCF-ICC)
Nov 10, 2020·European Journal of Paediatric Neurology : EJPN : Official Journal of the European Paediatric Neurology Society·Arlette L BruijstensK Rostasy
Nov 14, 2020·European Journal of Paediatric Neurology : EJPN : Official Journal of the European Paediatric Neurology Society·Arlette L BruijstensK Rostasy

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