Clinical Characteristics of Pediatric Patients With Sellar and Suprasellar Lesions Who Initially Present With Central Diabetes Insipidus: A Retrospective Study of 55 Cases From a Large Pituitary Center in China.

Frontiers in Endocrinology
Xin JiBing Xing

Abstract

Purpose: To increase knowledge for the early differential diagnosis and accurate therapeutic strategies for pediatric patients with sellar or suprasellar region (SSR) lesions who initially present with central diabetes insipidus (CDI). Methods: This is a retrospective review of 55 pediatric patients (≤14 years old) with identified lesions in the SSR who initially presented with CDI at a large pituitary center between 2012 and 2018. The following data were summarized: demographic, clinical, endocrine, and neuroimaging data, intraoperative findings, histopathological findings, treatments, and prognosis. Results: In our group, the etiologies of the SSR lesions included germ cell tumors (GCTs, 74.5%), Langerhans cell histiocytosis (LCH, 18.2%), and craniopharyngioma (CP, 7.3%). Almost all patients (50/55, 90.9%) showed anterior pituitary dysfunction [multiple axes dysfunction (38), and isolated axis dysfunction (14)], while the GH/IGF-I axis was the most affected. Most GCT patients presented with various clinical manifestations besides CDI and had elevated β-HCG, whereas LCH and CP patients mostly presented few non-specific symptoms besides CDI and most had normal level tumor markers. Sellar MRI demonstrated that posterior pituitar...Continue Reading

References

Jan 1, 1992·International Journal of Radiation Oncology, Biology, Physics·K J MinehanE G Shaw
Aug 1, 1985·Journal of Neurosurgery·M T JenningsF Hochberg
Jan 1, 1995·Neuroradiology·M SumidaF Ikawa
Apr 1, 1997·Medical and Pediatric Oncology·V Broadbent, J Pritchard
Jul 1, 1997·Medical and Pediatric Oncology·K E RosenzweigN J Tarbell
Oct 6, 2000·The New England Journal of Medicine·M MaghnieM Aricò
May 16, 2002·Neuroradiology·L LiangY Ushio
Jul 9, 2003·Journal of Pediatric Hematology/oncology·Fabio Ottaviano, Jonathan L Finlay
Sep 1, 2005·Journal of Pediatric Endocrinology & Metabolism : JPEM·Jeerunda SantiprabhobTheerawat Buddawong
Feb 8, 2006·Journal of Pediatric Endocrinology & Metabolism : JPEM·F K GroteJ M Wit
Nov 3, 2006·Pituitary·John A Jane, Edward R Laws
Feb 9, 2007·European Journal of Endocrinology·Wolfgang SaegerStephan Petersenn
Dec 8, 2007·Clinical Neurology and Neurosurgery·Xiang-En ShiYong-Li Zhang
Dec 4, 2009·Endocrine Development·G MoranaA Rossi
Jan 2, 2010·Journal of Neurosurgery. Pediatrics·Robert E ElliottJeffrey H Wisoff
May 4, 2010·The Journal of Pediatrics·Nicole GroisUNKNOWN Histiocyte Society CNS LCH Study Group
Jan 27, 2011·Pediatric Radiology·Jason W Schroeder, L Gilbert Vezina
Apr 22, 2011·The Journal of Clinical Endocrinology and Metabolism·Hermann L Müller
Dec 14, 2011·Orphanet Journal of Rare Diseases·Sophie Ng Wing TinUNKNOWN French LCH study group
Dec 21, 2011·Pediatric Blood & Cancer·Bernhard FahrnerNicole Grois
Feb 10, 2012·The Journal of Clinical Endocrinology and Metabolism·Alain GautierUNKNOWN Craniopharyngioma Study Group
Mar 22, 2012·Hormone Research in Pædiatrics·Natascia Di IorgiMohamad Maghnie
May 2, 2012·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Ibrahim QaddoumiAmar Gajjar
Aug 11, 2012·Journal of Pediatric Endocrinology & Metabolism : JPEM·Gonul CatliEce Bober
Mar 15, 2013·Neuro-oncology·Michal CohenJill Hamilton
May 2, 2013·The Journal of Clinical Endocrinology and Metabolism·E Elowe-GruauS Puget
Aug 7, 2013·Journal of the Formosan Medical Association = Taiwan Yi Zhi·Shih-Yao LiuWen-Yu Tsai
Jun 2, 2015·The Journal of Clinical Endocrinology and Metabolism·David WernyChristian L Roth
Sep 9, 2015·Neurologia Medico-chirurgica·Paul Steinbok
Sep 16, 2015·The Lancet Oncology·Matthew J MurrayJames C Nicholson
Oct 16, 2015·Hematology/oncology Clinics of North America·Chalinee Monsereenusorn, Carlos Rodriguez-Galindo
May 10, 2016·Best Practice & Research. Clinical Endocrinology & Metabolism·Elizabeth DabrowskiDonald Zimmerman
Jun 13, 2017·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Hanhui FuBing Xing
Sep 26, 2017·Pediatric Blood & Cancer·E Ann YehUNKNOWN North American Consortium for Histiocytosis
Sep 14, 2018·Journal of Cancer Research and Clinical Oncology·Xin LianFuquan Zhang
May 3, 2019·International Journal of Endocrinology·Wendong LiuGuimei Li

❮ Previous
Next ❯

Citations

Mar 27, 2021·Journal of Neuroendocrinology·Anna AngelousiGregory Kaltsas

❮ Previous
Next ❯

Methods Mentioned

BETA
biopsy
biopsies
PLAP

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists
Hiba Masri-IraqiIlan Shimon
© 2021 Meta ULC. All rights reserved