Clinical characteristics of primary Epstein Barr virus hepatitis with elevation of alkaline phosphatase and γ-glutamyltransferase in children

Yonsei Medical Journal
Soo In YangJae Young Kim

Abstract

The aim of the present study was to evaluate the clinical characteristics of the primary Epstein-Barr virus (EBV) hepatitis with elevation of both serum alkaline phosphatase (ALP) and γ-glutamyltransferase (γ-GT) levels in children. A retrospective study was performed by reviewing of the medical records of 36 patients who were diagnosed with primary EBV hepatitis. The patients were divided into 2 groups: patients with elevated serum ALP and γ-GT levels (group 1) and patients without (group 2). The classic features of infectious mononucleosis (fever, pharyngitis and/or tonsillitis, and cervical lymphadenitis) were seen in 20 (57.1%) of group 1 patients and 18 (50.0%) of group 2 patients. Hepatitis with elevated serum ALP and γ-GT levels were present in 14 (38.9%) of the all patients. Of these patients, Jaundice occurred in only 2 (5.6%). The mean levels of aspartate aminotransferase and alanine aminotransferase (ALT) as well as the number of patients with ALT greater than 400 IU/L were significantly different between the groups (177 IU/L vs. 94 IU/L, 418 IU/L vs. 115 IU/L, and 50.0% vs. 13.6%; p=0.001, p=0.001, p=0.026, respectively). The mean duration of elevated serum ALT levels was 17.5 days in group 1 and 9.0 days in group 2...Continue Reading

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Citations

Dec 3, 2014·Clinics in Liver Disease·Alisha M Mavis, Estella M Alonso
Jul 20, 2016·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Lisa KottanattuGregorio P Milani
Feb 20, 2018·Experimental and Therapeutic Medicine·Li ZhangKun Song
Mar 7, 2019·Case Reports in Pediatrics·Hassan El KhatibNahida El-Rifai
Feb 18, 2020·Clinical Practice and Cases in Emergency Medicine·Jessica Herold, Felipe Grimaldo

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