Clinical characteristics, risk factors and long-term outcome of 114 patients with folliculotropic mycosis fungoides

Archives of Dermatological Research
Iris WieserMadeleine Duvic

Abstract

Folliculotropic mycosis fungoides (FMF) is a distinct variant of mycosis fungoides (MF) where atypical T-cells invade the hair follicles. The objective was to assess the clinical features, risk factors for progression, long-term outcome and response to treatment modalities in a large cohort of FMF patients. We, therefore, conducted a single-center retrospective study, reviewing 114 patients with FMF seen from 1987 to 2015 at the cutaneous T-cell lymphoma clinic of the MD Anderson Cancer Center. The mean age at diagnosis of FMF was 57.1 ± 13.5 years. The male to female ratio was 1.2:1. MF stage IA (n = 50, 43.9%) was the most common diagnosed stage, followed equally by stages IB and IIB (n = 23, 20.2%, respectively). Eighty-six patients (75.4%) suffered from pruritus. Concomitant hair loss was observed in 37 (32.5%) subjects. The median number of different treatment modalities used per patient was 4 (range 1-12). Low-dose radiation was beneficial in clearing therapy refractory lesions. The overall survival was influenced by several factors, including advanced age (>65), late stages and the presence of large cell transformation (LCT). Thirty-three of 113 patients (29.2%) progressed to more advanced stages and 26 (23.0%) died, wit...Continue Reading

References

Jul 27, 1999·The British Journal of Dermatology·C D KlemkeC E Orfanos
Sep 1, 1999·The British Journal of Dermatology·E HodakM David
Feb 5, 2005·Blood·Rein WillemzeChris J L M Meijer
Mar 23, 2005·Archives of Dermatology·Marie-France DemierreDonald Miller
Jan 4, 2007·The British Journal of Dermatology·D NashanR Stadler
Feb 9, 2007·The British Journal of Dermatology·P Gerami, J Guitart
Aug 28, 2007·The American Journal of Surgical Pathology·Pedram Gerami, Joan Guitart
Jun 19, 2008·Archives of Dermatology·Pedram GeramiJoan Guitart
Jan 19, 2010·Journal of the American Academy of Dermatology·Cristina MuniesaOctavio Servitje
Mar 19, 2014·Journal of the American Academy of Dermatology·Emmilia HodakDan Ben-Amitai
Nov 19, 2014·Journal of the European Academy of Dermatology and Venereology : JEADV·M MarschalkóJ Csomor
Nov 22, 2014·The American Journal of Dermatopathology·Christine S AhnOmar P Sangüeza
Dec 9, 2014·Indian Journal of Dermatology·Nidhi JindalVk Jain
Oct 20, 2015·Journal of the American Academy of Dermatology·Danielle Nicole BrownMadeleine Duvic
Dec 26, 2015·Clinical Lymphoma, Myeloma & Leukemia·Rakhshandra TalpurMadeleine Duvic
Dec 30, 2015·International Journal of Dermatology·Janyana M D DeonizioJosé Antonio Sanches
Feb 26, 2016·CA: a Cancer Journal for Clinicians·Carol E DeSantisAhmedin Jemal
Jun 2, 2016·Journal of the American Academy of Dermatology·Emmilia HodakMeora Feinmesser
Jun 9, 2016·JAMA Dermatology·Suzanne van SantenRein Willemze

❮ Previous
Next ❯

Citations

Jul 25, 2019·Archives of Pathology & Laboratory Medicine·Alejandro A GruAndrea L Salavaggione
Nov 30, 2019·International Journal of Dermatology·Polytimi SidiropoulouAlexander Stratigos
May 12, 2018·Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG·Christina MitteldorfWerner Kempf
Jul 1, 2020·Journal of the European Academy of Dermatology and Venereology : JEADV·C W LaggisD Wada
Oct 22, 2019·International Journal of Dermatology·Incilay Kalay YildizhanAylin Heper
May 5, 2018·Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG·Christina MitteldorfWerner Kempf
May 8, 2020·Journal of the National Comprehensive Cancer Network : JNCCN·Neha Mehta-ShahYoun H Kim
Jan 26, 2021·The American Journal of Dermatopathology·Huma ShamimNneka Comfere
Dec 31, 2020·Journal of Clinical Medicine·Iris Wohlmuth-WieserRaed Alhusayen
Apr 17, 2021·Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG·Iris Wohlmuth-Wieser
Mar 13, 2021·Journal of the European Academy of Dermatology and Venereology : JEADV·M SławińskaI Zalaudek

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.