Clinical characterization of a familial degenerative myelopathy in Pembroke Welsh Corgi dogs

Journal of Veterinary Internal Medicine
Joan R CoatesDavid A Williams

Abstract

Adult dogs with degenerative myelopathy (DM) have progressive ataxia and paresis of the pelvic limbs, leading to paraplegia and euthanasia. Although most commonly reported in German Shepherd dogs, high disease prevalence exists in other breeds. Our aim was the clinical and histopathologic characterization of familial degenerative myelopathy (FDM) in Pembroke Welsh Corgi (PWC) dogs. Twenty-one PWCs were prospectively studied from initial diagnosis until euthanasia. Neurologic examination, blood tests, cerebrospinal fluid (CSF) analysis, electrodiagnostic testing, and spinal imaging were performed. Concentrations of 8-iso-prostaglandin F2alpha (8-isoprostane) were measured in CSF. Routine histochemistry was used for neuropathology. Deoxyribonucleic acid and pedigrees were collected from 110 dogs. Median duration of clinical signs before euthanasia was 19 months. Median age at euthanasia was 13 years. All dogs were nonambulatory paraparetic or paraplegic, and 15 dogs had thoracic limb weakness at euthanasia. Electrodiagnostic testing and spinal imaging were consistent with noncompressive myelopathy. No significant difference was detected in 8-isoprostane concentrations between normal and FDM-affected dogs. Axonal and myelin degene...Continue Reading

Citations

Feb 4, 2009·Proceedings of the National Academy of Sciences of the United States of America·Tomoyuki AwanoJoan R Coates
Jun 2, 2011·The Journal of Veterinary Medical Science·Mizue OgawaHiroyuki Nakayama
Jun 28, 2011·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Peter I JoyceAbraham Acevedo-Arozena
Nov 23, 2011·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Kate L TsaiLeigh Anne Clark
Aug 19, 2011·Journal of Veterinary Internal Medicine·F A WiningerJ R Coates
Feb 15, 2014·Journal of Veterinary Internal Medicine·R ZengG S Johnson
Feb 11, 2016·Drug Discovery Today·Pascaline ClercCatherine Willett
May 18, 2016·Proceedings of the National Academy of Sciences of the United States of America·Emma L IvanssonKerstin Lindblad-Toh
Apr 26, 2016·The Journal of Veterinary Medical Science·Kanae OyakeHiroaki Kamishina

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