Clinical Characterization of Children Presenting to the Hospital with Enterovirus D68 Infection During the 2014 Outbreak in St. Louis

The Pediatric Infectious Disease Journal
Anthony OrvedahlMythili Srinivasan

Abstract

The largest known outbreak of enterovirus D68 (EV-D68) infections occurred during 2014. The goal of our study is to characterize the illness severity and clinical presentation of children infected with EV-D68 in comparison to non-EV-D68-human rhinoviruses/enteroviruses (HRV/EV). Our study is a retrospective analysis of severity level, charges and length of stay of children who presented to St. Louis Children's Hospital from August 8, 2014 to October 31, 2014 and tested positive for EV-D68 in comparison to non-EV-D68-HRV/EV-infected patients. Chart review was performed for all EV-D68-infected patients and age and severity matched non-EV-D68-HRV/EV-infected patients. There was a striking increase in hospital census in August of 2014 in our hospital with simultaneous increase in the number of patients with EV-D68 infection. There was no significant difference in severity of illness, length of stay or total charges between EV-D68-infected and non-EV-D68-HRV/EV-infected children. EV-D68 infection was characterized by presenting complaints of difficulty breathing (80%) and wheezing (67%) and by findings of tachypnea (65%), wheezing (71%) and retractions (65%) on examination. The most common interventions were albuterol (79%) and cort...Continue Reading

References

Mar 1, 1967·American Journal of Epidemiology·J H SchiebleE H Lennette
Dec 23, 2014·Emerging Infectious Diseases·Kristine M WylieGregory A Storch
Dec 24, 2014·Influenza and Other Respiratory Viruses·Karoline BragstadAnne-Marte B Kran
Feb 26, 2015·Annals of the American Thoracic Society·Christopher M OermannMary Anne Jackson
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Sep 14, 2015·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Randy PoelmanUNKNOWN ESCV-ECDC EV-D68 study group
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Citations

Jan 31, 2017·Pediatric Pulmonology·Charles B FosterGiovanni Piedimonte
Mar 3, 2018·Influenza and Other Respiratory Viruses·Timothy J SavageAlpana Waghmare
Dec 1, 2017·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Mila M PrillM Steven Oberste
Dec 28, 2018·Journal of the Pediatric Infectious Diseases Society·Matthew R Vogt, James E Crowe
Oct 16, 2016·Journal of Paediatrics and Child Health·David Isaacs
Oct 20, 2018·Emerging Infectious Diseases·Mythili SrinivasanGregory A Storch
Jul 2, 2019·Japanese Journal of Infectious Diseases·Agca Harun, Ener Beyza

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