Clinical chorioamnionitis at term VI: acute chorioamnionitis and funisitis according to the presence or absence of microorganisms and inflammation in the amniotic cavity

Journal of Perinatal Medicine
R RomeroYeon Mee Kim

Abstract

Neonates born to mothers with clinical chorioamnionitis at term are at an increased risk of infection. Acute subchorionitis, chorioamnionitis, and funisitis are considered placental histologic features consistent with acute inflammation according to the Society for Pediatric Pathology. The objectives of this study were to examine the performance of placental histologic features in the identification of: 1) microbial-associated intra-amniotic inflammation (intra-amniotic infection); and 2) fetal inflammatory response syndrome (FIRS). This retrospective cohort study included women with the diagnosis of clinical chorioamnionitis at term (n=45), who underwent an amniocentesis to determine: 1) the presence of microorganisms using both cultivation and molecular biologic techniques [polymerase chain reaction (PCR) with broad range primers]; and 2) interleukin (IL)-6 concentrations by enzyme-linked immunosorbent assay (ELISA). The diagnostic performance (sensitivity, specificity, accuracy, and likelihood ratios) of placental histologic features consistent with acute inflammation was determined for the identification of microbial-associated intra-amniotic inflammation and FIRS. 1) The presence of acute histologic chorioamnionitis and fu...Continue Reading

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Citations

Dec 16, 2016·Clinical Microbiology Reviews·Emma L SweeneyChristine L Knox
Jan 9, 2020·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Jose GalazNardhy Gomez-Lopez
Oct 30, 2020·Frontiers in Immunology·Krishna Rao Maddipati
Apr 4, 2021·Journal of Clinical Medicine·Greta BalciunieneDiana Ramasauskaite
Jul 7, 2021·Journal of Perinatal Medicine·Eunjung JungChaur-Dong Hsu

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Methods Mentioned

BETA
PCR
cesarean section
biopsy

Software Mentioned

SPSS

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