Clinical classification and plaque morphology determined by optical coherence tomography in unstable angina pectoris

The American Journal of Cardiology
Masato MizukoshiTakashi Akasaka

Abstract

Unstable angina pectoris (UAP) is categorized with the Braunwald classification. However, the association of clinical presentation and plaque structure/function has not yet been elucidated in relation to cause. We used optical coherence tomography to investigate this relation. One hundred fifteen patients with primary UAP were categorized according to the Braunwald classification. Patients with class I UAP had the highest frequency of ulcers without fibrous cap disruption (p = 0.003) and the smallest minimum lumen area (class I, median 0.70 mm(2), quartiles 1 to 3 0.42 to 1.00; class II, 1.80 mm(2), 1.50 to 2.50; class III, 2.31 mm(2), 1.21 to 3.00; p <0.001). Patients with class II UAP had the highest frequency of coronary spasm (p <0.001) and the lowest frequency of thrombi (p <0.001). Patients with class III UAP had the highest frequency of plaque ruptures (p <0.001), the thinnest fibrous cap (class I, median 140 microm, quartile 1 to 3 90 to 160; class II, 150 microm, 120 to 160; class III, 60 microm, 40 to 105; p <0.001), and the highest frequency of thin cap fibroatheromas (p <0.001) and spotty calcifications (p <0.001). In conclusion, the structures/functions of culprit lesions on optical coherence tomograms differ in th...Continue Reading

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Citations

Jun 15, 2011·Circulation Journal : Official Journal of the Japanese Circulation Society·Yasumi UchidaNobuyuki Hiruta
Sep 24, 2011·Cardiology Research and Practice·Takashi KuboTakashi Akasaka
Jul 15, 2015·The International Journal of Cardiovascular Imaging·Charis CostopoulosMartin R Bennett
Jan 23, 2016·Radiology Research and Practice·Sunny GoelOn Chen
Jun 28, 2013·Thrombosis and Haemostasis·Gian Marco RosaFabrizio Montecucco
May 25, 2013·Annals of the New York Academy of Sciences·Troy C SarichPeter M DiBattiste
Nov 9, 2011·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Glenn N LevineUNKNOWN Society for Cardiovascular Angiography and Interventions
Nov 19, 2011·Journal of the American College of Cardiology·Robert P Giugliano, Eugene Braunwald
Jun 18, 2010·Journal of cardiology·Takashi AkasakaToshio Imanishi
Oct 29, 2015·European Heart Journal Cardiovascular Imaging·Mario IannacconeFiorenzo Gaita
Dec 4, 2014·Expert Review of Cardiovascular Therapy·Adam J BrownMartin R Bennett

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