Abstract
Two independent, investigator-blinded, multicenter, randomized clinical trials compared the clinical and bacteriologic efficacy and safety of two oral antibiotics, cefuroxime axetil and amoxicillin/clavulanate, in the treatment of patients with secondary bacterial infections of acute bronchitis (hereafter denoted acute bronchitis). Three hundred sixty patients with signs and symptoms of acute bronchitis were enrolled at 22 centers and were randomly assigned to receive 10 days of treatment with either cefuroxime axetil 250 mg twice daily (BID) (n= 177) or amoxicillin/clavulanate 500 mg three times daily (TID) (n = 183). Patients were assessed for both clinical and bacteriologic responses once during treatment (at 3 to 5 days) and twice after treatment (at 1 to 3 days and at 13 to 15 days). Bacteriologic assessments were based on sputum specimen cultures obtained before treatment and, when possible, after treatment. Organisms were isolated from the pretreatment sputum specimens of 162 (45%) of 360 patients, with the primary pathogens being Haemophilus influenzae, Haemophilus parainfluenzae, Streptococcus pneumoniae, Moraxella catarrhalis, and Staphylococcus aureus (28%, 25%, 11%, 9%, and 8% of isolates, respectively). Thirty-four...Continue Reading
References
Sep 1, 1992·The American Journal of Medicine·A E CamachoJ J Collins
Jan 1, 1991·Diagnostic Microbiology and Infectious Disease·G V Doern
Mar 1, 1991·The Journal of Antimicrobial Chemotherapy·A G ArguedasM I Marks
Nov 1, 1990·Antimicrobial Agents and Chemotherapy·J H JorgensenJ S Redding
Jul 1, 1990·Diagnostic Microbiology and Infectious Disease·G V Doern, T A Tubert
Oct 1, 1990·Southern Medical Journal·M PichicheroP M Darden
Jan 1, 1988·Antimicrobial Agents and Chemotherapy·C C Knapp, J A Washington
Nov 1, 1987·Biopharmaceutics & Drug Disposition·A FinnJ Chubb
Mar 1, 1987·The Journal of Antimicrobial Chemotherapy·F P MaesenC Baur
Jan 1, 1984·Antimicrobial Agents and Chemotherapy·S M HardingJ Ayrton
Feb 1, 1984·The Journal of Antimicrobial Chemotherapy·P E Williams, S M Harding
Aug 1, 1993·Antimicrobial Agents and Chemotherapy·J A WashingtonC C Knapp
Mar 1, 1993·Diagnostic Microbiology and Infectious Disease·P R MurrayE H Gerlach