Clinical comparison of liquid-based and conventional cytology of oral brush biopsies: a randomized controlled trial

Head & Face Medicine
Constanze OlmsTorsten W Remmerbach

Abstract

Exfoliative cytology performed on oral brush samples can help dentists to decide, whether a given oral lesion is (pre-) malignant. The use of non-invasive brush biopsies as an auxiliary tool in the diagnosis of oral mucosal lesions has gained renewed interest since improvements in cytological techniques such as the development of adjuvant diagnostic tools and liquid-based cell preparation techniques. The aim of this study was to compare the quality of two different preparation techniques (cell collectors): the conventional transfer procedure to glass slides and the so-called liquid-based cytology preparation method. Cell smears were collected from 10 orally healthy individuals (mean age: 24 years) from the palatine mucosa at two different times (baseline and 4 weeks later). Slides of both techniques were stained by Giemsa (n = 40) and May-Gruenwald Giemsa (n = 40). The statistical analysis was performed with Excel. On specimen analysis, the liquid-based cytology showed statistically significant improvement compared to conventional glass sides (p < 0.001). Thin layers, which were performed by liquid-based cytology showed significantly better results in the parameters (p < 0.001): uniform distribution, cellular overlapping, cellu...Continue Reading

References

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Citations

Sep 3, 2020·Diagnostic Cytopathology·Yuliana Andrea Osorio-OsornoMonica Tatiana Parada-Sanchez
Jun 20, 2018·Dentistry Journal·Constanze OlmsCatalina Suzana Stingu
Sep 12, 2020·Diagnostic Pathology·Shintaro SukegawaYoshihiko Furuki
Jul 28, 2020·Journal of Oral Biology and Craniofacial Research·Monal YuwanatiSandeep Kumar Pathak

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Methods Mentioned

BETA
biopsies

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