Clinical consequences of non-compliance with directly observed therapy short course (DOTS): Story of a recurrent defaulter

International Journal of Mycobacteriology
Liaqat Ali ChaudhryJiri Pazdirek

Abstract

In 1993, the World Health Organization (WHO) declared tuberculosis (TB) a global emergency, and subsequently introduced the directly observed therapy short course (DOTS) strategy, a technical and management package, based on the earlier work of the International Union Against Tuberculosis and Lung Disease (IUATLD) and international experience with DOTS, which strategy beyond a doubt has played a great role in the initial success of this program, especially in hospitalized patients under the initial intensive phase of 4-drug, anti-TB treatment with Isoniazid, Rifampicin, Pyrazinamide and Ethambutol. This results in rapid clinical well-being and early sputum conversion. This is indeed epidemiologically very important to break the chain of infection. Despite successful implementation of most of the elements of this strategy in several African countries and settings, TB case rates continue to escalate where the prevalence of HIV infection is high. There are also various other reasons which render the patients defaulter. Non-compliance is not only detrimental to the defaulters themselves as seen in this case study, but overall exposes the community to increased risk. Development of acquired resistance is more common in these patient...Continue Reading

Citations

Mar 1, 2013·International Journal of Mycobacteriology·Liaqat Ali Chaudhry, Shehab Al-Solaiman
May 18, 2021·Journal of Clinical Tuberculosis and Other Mycobacterial Diseases·Rajesh Kumar YadavRenuka Ojha

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