Clinical consequences of reinnervation disorders after focal peripheral nerve lesions

Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology
Josep Valls-SoléJoão Costa

Abstract

Axonal regeneration and organ reinnervation are the necessary steps for functional recovery after a nerve lesion. However, these processes are frequently accompanied by collateral events that may not be beneficial, such as: (1) Uncontrolled branching of growing axons at the lesion site. (2) Misdirection of axons and target organ reinnervation errors, (3) Enhancement of excitability of the parent neuron, and (4) Compensatory activity in non-damaged nerves. Each one of those possible problems or a combination of them can be the underlying pathophysiological mechanism for some clinical conditions seen as a consequence of a nerve lesion. Reinnervation-related motor disorders are more likely to occur with lesions affecting nerves which innervate muscles with antagonistic functions, such as the facial, the laryngeal and the ulnar nerves. Motor disorders are better demonstrated than sensory disturbances, which might follow similar patterns. In some instances, the available examination methods give only scarce evidence for the positive diagnosis of reinnervation-related disorders in humans and the diagnosis of such condition can only be based on clinical observation. Whatever the lesion, though, the restitution of complex functions suc...Continue Reading

References

Jul 1, 1977·Journal of Neurology, Neurosurgery, and Psychiatry·W Trojaborg
Oct 1, 1976·Archives of Neurology·S Satya-Murti, R B Layzer
Jan 1, 1991·The Annals of Otology, Rhinology, and Laryngology·J L NettervilleR H Ossoff
Jan 1, 1990·Progress in Neurobiology·M J Titmus, D S Faber
Feb 1, 1989·The Annals of Otology, Rhinology, and Laryngology·R L Crumley
Aug 1, 1986·Archives of Neurology·B ScherokmanE Maniglia
May 1, 1988·Journal of Neurology, Neurosurgery, and Psychiatry·J W LanceJ G Morris
Jul 1, 1985·Journal of Neurology, Neurosurgery, and Psychiatry·G D Schott
Jul 1, 1994·Movement Disorders : Official Journal of the Movement Disorder Society·G PavesiF Gemignani
Sep 1, 1994·Journal of Reconstructive Microsurgery·G LundborgQ Zhao
Aug 1, 1993·Brain : a Journal of Neurology·K P BhatiaC D Marsden
Jan 1, 1993·Movement Disorders : Official Journal of the Movement Disorder Society·C G GarnerW H Oertel
Jan 1, 1996·Movement Disorders : Official Journal of the Movement Disorder Society·V ScaioliG Broggi
Apr 23, 1999·Clinical Autonomic Research : Official Journal of the Clinical Autonomic Research Society·V TugnoliD De Grandis
May 20, 1999·The Laryngoscope·M K Wani, G E Woodson
Apr 7, 2000·Movement Disorders : Official Journal of the Movement Disorder Society·S FruchtB Ford
Apr 25, 2000·The Annals of Otology, Rhinology, and Laryngology·R L Crumley
May 24, 2000·The Annals of Otology, Rhinology, and Laryngology·R C Paniello, S E West
Oct 6, 2000·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·D MancaM A Callejas
Dec 18, 2001·Muscle & Nerve·H J GilhuisM J Zwarts
Jan 24, 2003·The Journal of Comparative Neurology·Bindu RajanJustin C McArthur
Sep 5, 2003·Clinical Autonomic Research : Official Journal of the Clinical Autonomic Research Society·Robert VetrugnoPasquale Montagna
Oct 23, 2003·Muscle & Nerve·Leena PuksaBjörn Falck
Nov 19, 2003·The European Journal of Neuroscience·Natalia GorodetskayaWilfrid Jänig
Dec 4, 2003·Journal of the Peripheral Nervous System : JPNS·Tessa GordonJ Gordon Boyd

❮ Previous
Next ❯

Citations

Dec 14, 2012·Expert Review of Neurotherapeutics·Gonzalo Barraza-SandovalJosep Valls-Solé
Feb 24, 2016·Plastic Surgery International·K S HouschyarJ van Schoonhoven
Oct 28, 2011·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Josep Valls-Sole
Nov 22, 2011·Muscle & Nerve·Jordi Casanova-MollaJosep Valls-Solé
Mar 6, 2015·Frontiers in Cellular Neuroscience·Oscar A Carballo-Molina, Iván Velasco
Apr 28, 2016·Brain Research·Vicente ValenzuelaFelipe A Court

❮ Previous
Next ❯

Related Concepts

Related Feeds

ALS: Transposon de-silencing

Transposon silencing is a form of transcriptional gene silencing. These gene silencing mechanisms are impaired in Amyotrophic lateral sclerosis (ALS). Here are the latest discoveries pertaining to transposon silencing and this disease.