Clinical considerations in the use of sublingual immunotherapy for allergic rhinitis

American Journal of Rhinology & Allergy
Stella LeeMichael S Benninger

Abstract

Allergen immunotherapy (AIT) has been in practice for more than 100 years. However, research in novel routes and delivery methods of immunotherapy to treat allergic rhinitis (AR) and conjunctivitis has only recently occurred in the United States, where the predominant form of AIT provided is largely via a subcutaneous immunotherapy (SCIT) route. AIT may prevent new sensitizations, improve symptoms, decrease medication usage, and prevent allergic asthma. Although AIT is the only potentially curative treatment for AR, access and adherence continue to be problematic. Only a fraction of eligible patients actually undergo treatment, and attrition rates are high. An obvious limitation of SCIT includes the requirement of regular injections to be provided in the physician's office due to the potential for anaphylaxis. Sublingual immunotherapy (SLIT) for home administration has been investigated as a potential alternative to address this limitation of SCIT. A literature review was performed including the current findings from randomized clinical trials and meta-analyses with a discussion of the most recent evidence for the efficacy, safety, and dosing of allergen SLIT. The current data suggest that SLIT is effective for treatment of sea...Continue Reading

References

Jun 13, 1998·The Journal of Pharmacy and Pharmacology·H Seager
Feb 14, 2002·The Journal of Allergy and Clinical Immunology·Christian MöllerUlrich Wahn
Feb 27, 2004·The American Journal of Medicine·Andrew M WilsonKrishnan Parameswaran
Jun 24, 2004·Archives of Disease in Childhood·S Miceli SopoS Tripodi
Oct 14, 2004·The Journal of Allergy and Clinical Immunology·Elio NovembreAlberto Vierucci
May 6, 2006·The Journal of Allergy and Clinical Immunology·Linda S CoxHarold S Nelson
Jan 29, 2008·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Esther RöderRoy Gerth van Wijk
Dec 3, 2008·The Journal of Allergy and Clinical Immunology·Ulrich WahnUNKNOWN SLIT Study Group
Mar 28, 2009·Current Opinion in Allergy and Clinical Immunology·Desiree Larenas-Linnemann
Aug 4, 2009·The Journal of Allergy and Clinical Immunology·Friedrich HorakMartine Le Gall
Jan 21, 2010·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Linda Cox, Lars Jacobsen
Feb 11, 2010·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Michael BenningerMichael Kaliner
Mar 10, 2010·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·M FockeR Valenta
Jul 22, 2010·International Journal of Immunopathology and Pharmacology·G CiprandiF Frati
Aug 3, 2010·The Journal of Allergy and Clinical Immunology·Danilo Di BonaGabriele Di Lorenzo
Sep 8, 2010·The Journal of Allergy and Clinical Immunology·Jan L BrozekUNKNOWN Grading of Recommendations Assessment, Development and Evaluation Working Group
Dec 3, 2010·The Journal of Allergy and Clinical Immunology·Linda CoxDana Wallace
Jan 8, 2011·The Journal of Allergy and Clinical Immunology·Michael BlaissDavid P Skoner
Jan 8, 2011·The Journal of Allergy and Clinical Immunology·Harold S NelsonDavid I Bernstein
Mar 30, 2011·Allergy·S RadulovicStephen Durham
May 3, 2011·Immunology and Allergy Clinics of North America·O PfaarL Klimek
May 31, 2011·The Journal of Allergy and Clinical Immunology·Paolo Maria MatricardiAnnemie Narkus
May 31, 2011·Otolaryngologic Clinics of North America·Sandra Y Lin, Bryan Leatherman
Jun 28, 2011·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Ji-Eun LeeDong-Young Kim
Aug 19, 2011·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·M A CalderonS R Durham
Oct 12, 2011·Current Opinion in Allergy and Clinical Immunology·Aarif O EifanStephen R Durham
Nov 15, 2011·European Journal of Internal Medicine·Giorgio Ciprandi, Ignazio Cirillo
Nov 24, 2011·Clinical & Developmental Immunology·Philippe Moingeon, Laurent Mascarell
Jan 17, 2012·The Journal of Allergy and Clinical Immunology·Moisés A CalderónPascal Demoly
Mar 1, 2012·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Thomas J Grier
Mar 22, 2012·International Forum of Allergy & Rhinology·Nicole M Hsu, William R Reisacher
Apr 14, 2012·Current Opinion in Allergy and Clinical Immunology·Moises A CalderonOliver Pfaar
Jun 9, 2012·The Journal of Allergy and Clinical Immunology·Ravi S SwamyKari C Nadeau
Oct 26, 2012·Human Vaccines & Immunotherapeutics·Antonio Cappella, Stephen R Durham
Nov 6, 2012·The Journal of Allergy and Clinical Immunology·Linda S CoxRobert K Zeldin

❮ Previous
Next ❯

Citations

Nov 7, 2016·The Journal of Allergy and Clinical Immunology. in Practice·Tolly G EpsteinSten Dreborg
Feb 1, 2017·Expert Opinion on Investigational Drugs·Peter A RickettiThomas B Casale
Apr 14, 2018·American Journal of Rhinology & Allergy·Silviya M NovakovaJivko L Peichev
Sep 23, 2016·American Journal of Rhinology & Allergy·Tugba OktemerCemal Cingi
Sep 23, 2016·American Journal of Rhinology & Allergy·Ethem ŞahinCemal Cingi
Sep 23, 2019·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Ji-A KimKyu-Sup Cho
Apr 23, 2016·Allergy & Rhinology·William R ReisacherGuy Tropper
Oct 14, 2017·American Journal of Rhinology & Allergy·Ethem ŞahinCemal Cingi
Oct 14, 2017·American Journal of Rhinology & Allergy·Tugba OktemerCemal Cingi

❮ Previous
Next ❯

Methods Mentioned

BETA
pharmacotherapy

Related Concepts

Related Feeds

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.

Asthma

This feed focuses in Asthma in which your airways narrow and swell. This can make breathing difficult and trigger coughing, wheezing and shortness of breath.

Allergies & Environmental Factors

Environmental factors are strongly associated with the prevalence of allergies and are an increasing health concern worldwide. Discover the latest research on Allergies and Environmental Factors here.

Anaphylaxis

Anaphylaxis is a serious allergic reaction that is rapid in onset and may cause death.

Related Papers

Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology
Moisés A CalderónH Nolte
The Journal of Allergy and Clinical Immunology. in Practice
Harold S Nelson
Human Vaccines & Immunotherapeutics
Antonio Cappella, Stephen R Durham
European Annals of Allergy and Clinical Immunology
Franco FratiG Senna
© 2021 Meta ULC. All rights reserved