Clinical contribution of myositis-related antibodies detected by immunoblot to idiopathic inflammatory myositis: A one-year retrospective study

Autoimmunity
Marie Lecouffe-DespretsJérôme C Martin

Abstract

In this study, we aimed at evaluating the contribution of an extended myositis-related antibodies (Abs) determination by immunoblot to the diagnosis, classification, and prognosis of idiopathic inflammatory myositis (IIM). Medical records of all the patients (n = 237) with myositis-related Ab requests addressed to our department over a one-year period were retrospectively analyzed. Patients were classified as IIM, auto-immune disease (AID) other than IIM, and other diagnosis, and examined for their Ab profiles as determined by immunoblot. Ab positivity was qualified semi-quantitatively as low or strong according to the manufacturer's recommendations. Among the 45 Ab-positive patients, 49% were diagnosed an IIM, 22% another AID, and 29% another diagnosis. The clinico-serological patterns of the myositis-related Ab+ patients fully recapitulated those described in the literature. Among non-IIM patients, anti-PM-Scl was the most frequently detected Ab (38%), followed by anti-Mi-2 (15%), and anti-OJ (12%). Importantly, strong Ab positivity was significantly more detected in IIM vs. non-IIM patients (82% vs. 35%; p = .002). This difference was further increased when comparing MSAs only (95% vs. 36%; p = .0004). Accordingly, strong Ab...Continue Reading

References

Jun 22, 2005·Autoimmunity·Anna GhirardelloAndrea Doria
Sep 1, 2007·Arthritis and Rheumatism·Kerry B StoneDana P Ascherman
Mar 17, 2009·Autoimmunity Reviews·Johan RönnelidIngrid E Lundberg
Apr 28, 2009·Autoimmunity Reviews·Anna GhirardelloAndrea Doria
Oct 23, 2009·The British Journal of Dermatology·I MarieF Jouen
Apr 26, 2011·Respiratory Medicine·Kizuku WatanabeMichiaki Mishima
Sep 21, 2013·Clinical Reviews in Allergy & Immunology·Sarah Tansley, Harsha Gunawardena
Apr 30, 2015·The New England Journal of Medicine·Marinos C Dalakas
Oct 30, 2016·International Journal of Rheumatic Diseases·Teck Choon TanStephen Adelstein
Apr 27, 2016·Pathology·Chris BundellAndrew McLean-Tooke
Aug 19, 2016·Current Opinion in Neurology·Olivier BenvenisteYves Allenbach
Jan 12, 2017·Neuropathology and Applied Neurobiology·Y AllenbachW Stenzel

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Citations

Sep 8, 2019·Annals of the Rheumatic Diseases·Maria InfantinoNicola Bizzaro

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