Clinical Control of HIV-1 by Cytotoxic T Cells Specific for Multiple Conserved Epitopes

Journal of Virology
Hayato MurakoshiMasafumi Takiguchi

Abstract

Identification and characterization of CD8(+) T cells effectively controlling HIV-1 variants are necessary for the development of AIDS vaccines and for studies of AIDS pathogenesis, although such CD8(+) T cells have been only partially identified. In this study, we sought to identify CD8(+) T cells controlling HIV-1 variants in 401 Japanese individuals chronically infected with HIV-1 subtype B, in which protective alleles HLA-B*57 and HLA-B*27 are very rare, by using comprehensive and exhaustive methods. We identified 13 epitope-specific CD8(+) T cells controlling HIV-1 in Japanese individuals, though 9 of these epitopes were not previously reported. The breadths of the T cell responses to the 13 epitopes were inversely associated with plasma viral load (P = 2.2 × 10(-11)) and positively associated with CD4 count (P = 1.2 × 10(-11)), indicating strong synergistic effects of these T cells on HIV-1 control in vivo. Nine of these epitopes were conserved among HIV-1 subtype B-infected individuals, whereas three out of four nonconserved epitopes were cross-recognized by the specific T cells. These findings indicate that these 12 epitopes are strong candidates for antigens for an AIDS vaccine. The present study highlighted a strategy...Continue Reading

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Citations

Jan 9, 2016·Molecular Therapy : the Journal of the American Society of Gene Therapy·Beatrice OndondoTomáš Hanke
Nov 20, 2015·Molecular Therapy : the Journal of the American Society of Gene Therapy·Sultan Abdul-JawadTomáš Hanke
Sep 13, 2016·Molecular Therapy. Methods & Clinical Development·Gaudensia MutuaThe Hiv-Core 004 Study Group
Feb 6, 2017·Molecular Therapy : the Journal of the American Society of Gene Therapy·Edmund G WeeTomáš Hanke
Jun 9, 2017·AIDS Research and Human Retroviruses·Leandro F TarossoEsper G Kallas
Oct 3, 2017·The Journal of Infectious Diseases·Takayuki ChikataMasafumi Takiguchi
Dec 15, 2017·Journal of Virology·Takayuki ChikataMasafumi Takiguchi
Apr 24, 2020·Journal of Virology·Ming-Han Chloe TsaiPhilip Goulder
Nov 9, 2018·Frontiers in Immunology·Enxiang PanCaijun Sun

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