Clinical correlates and prognostic impact of impaired iron storage versus impaired iron transport in an international cohort of 1821 patients with chronic heart failure

International Journal of Cardiology
Pedro MolinerJosep Comín-Colet

Abstract

To define iron deficiency in chronic heart failure (CHF), both, ferritin<100μg/L (indicating reduced iron storage) and transferrin saturation (TSAT)<20% (indicating reduced iron transport) are used. The aim of the study was to evaluate clinical outcomes and prognosis of either low ferritin or low TSAT in patients with CHF. We evaluated the clinical impact of impaired iron storage (IIS) and impaired iron transport (IIT) either alone or in combination compared to patients with normal iron status (NIS), in an international cohort of 1821 patients with CHF with a mean age of 66±13years and mean left ventricular ejection fraction of 35%±15. Isolated IIS was observed in 219 patients (12%), isolated IIT in 454 (25%) and coexistence of both conditions (IIS+IIT) were seen in 389 (21%). In adjusted models we found that patients with IIS+IIT and patients with isolated IIT had higher NT-proBNP levels (OR 2.2 [1.6-3.1] and OR 2.1 [1.5-2.9] respectively) and worse quality of life (OR 1.8 [1.2-2.7] and OR 1.7 [1.2-2.5] respectively) compared with isolated IIS. Multivariate Cox analyses showed that IIS+IIT and isolated IIT were independently associated with all-cause mortality (OR 1.41 [1.06-1.86] and OR 1.47 [1.13-1.92] respectively). Patient...Continue Reading

Citations

Feb 1, 2018·Circulation. Heart Failure·Niels Grote BeverborgPeter van der Meer
Sep 11, 2019·Critical Reviews in Clinical Laboratory Sciences·Patrice CacoubKatell Peoc'h
Oct 8, 2019·Journal of the American Heart Association·Giuseppe VergaroMichele Emdin
Oct 9, 2020·Health and Quality of Life Outcomes·Josep Comín-ColetSilvia Jiménez Merino
Nov 24, 2020·Disease Markers·Przemysław LeszekMarcin Kruszewski
Feb 24, 2021·European Journal of Preventive Cardiology·Jeness CampodonicoPiergiuseppe Agostoni
Mar 16, 2021·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·Patricia PalauJulio Núñez
Mar 24, 2021·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·Fraser J GrahamJohn G F Cleland
Sep 28, 2021·The Egyptian Heart Journal : (EHJ) : Official Bulletin of the Egyptian Society of Cardiology·Hassan Ismahel, Nadeen Ismahel

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anemia

Anemia develops when your blood lacks enough healthy red blood cells. Anemia of inflammation (AI, also called anemia of chronic disease) is a common, typically normocytic, normochromic anemia that is caused by an underlying inflammatory disease. Here is the latest research on anemia.