Clinical Correlates, Ethnic Differences, and Prognostic Implications of Perivascular Spaces in Transient Ischemic Attack and Ischemic Stroke

Stroke; a Journal of Cerebral Circulation
Kui-Kai LauPeter M Rothwell

Abstract

Perivascular spaces (PVSs) are considered markers of small vessel disease. However, their long-term prognostic implications in transient ischemic attack/ischemic stroke patients are unknown. Ethnic differences in PVS prevalence are also unknown. Two independent prospective studies were conducted, 1 comprising predominantly whites with transient ischemic attack/ischemic stroke (OXVASC [Oxford Vascular] study) and 1 comprising predominantly Chinese with ischemic stroke (University of Hong Kong). Clinical and imaging correlates, prognostic implications for stroke and death, and ethnic differences in basal ganglia (BG) and centrum semiovale (CS) PVSs were studied with adjustment for age, sex, vascular risk factors, and scanner strength. Whites with transient ischemic attack/ischemic stroke (n=1028) had a higher prevalence of both BG and CS-PVSs compared with Chinese (n=974; >20 BG-PVSs: 22.4% versus 7.1%; >20 CS-PVSs: 45.8% versus 10.4%; P<0.0001). More than 20 BG or CS-PVSs were both associated with increasing age and white matter hyperintensity, although associations with BG-PVSs were stronger (all P<0.0001). During 6924 patient-years of follow-up, BG-PVSs were also independently associated with an increased risk of recurrent isc...Continue Reading

References

Jan 9, 2010·Stroke; a Journal of Cerebral Circulation·Fergus N DoubalJoanna M Wardlaw
Feb 16, 2013·Journal of Neurology, Neurosurgery, and Psychiatry·Andreas CharidimouDavid J Werring
Apr 5, 2013·Neurology·Sergi Martinez-RamirezAnand Viswanathan
Jul 23, 2013·Lancet Neurology·Joanna M WardlawUNKNOWN STandards for ReportIng Vascular changes on nEuroimaging (STRIVE v1)
Nov 20, 2013·Journal of Neurology, Neurosurgery, and Psychiatry·Robert HurfordDavid J Werring
Mar 20, 2016·Cellular and Molecular Neurobiology·Joel RamirezSandra E Black

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Citations

Jul 4, 2018·International Journal of Stroke : Official Journal of the International Stroke Society·Kui Kai LauPeter M Rothwell
Aug 11, 2018·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Ryan A OpelMiranda M Lim
Dec 9, 2017·Journal of the American Heart Association·Kui Kai LauHenry Ka Fung Mak
Apr 19, 2019·Neurology·Robert HurfordUNKNOWN Oxford Vascular Study
Mar 18, 2020·American Journal of Alzheimer's Disease and Other Dementias·Danhong WuXueyuan Liu
Jul 28, 2020·Journal of the American Heart Association·Yuanyuan FangMinghuan Wang
Feb 26, 2020·Nature Reviews. Neurology·Joanna M WardlawUNKNOWN colleagues from the Fondation Leducq Transatlantic Network of Excellence on the Role of the Perivascular Space in Cerebral S
Oct 26, 2018·Stroke; a Journal of Cerebral Circulation·Kui Kai LauUNKNOWN Oxford Vascular Study
Aug 18, 2020·Journal of the American Heart Association·Anna LaveskogChengxuan Qiu
Oct 7, 2020·Stroke; a Journal of Cerebral Circulation·Ashley A PentonJose R Romero
Nov 6, 2020·Journal of Neurology, Neurosurgery, and Psychiatry·Robert HurfordUNKNOWN Oxford Vascular Study Phenotyped Cohort
Oct 20, 2019·Neurobiology of Aging·Marie-Gabrielle DuperronStéphanie Debette
May 20, 2021·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Xiaopeng ZongWeili Lin

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Software Mentioned

OXVASC

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