PMID: 8959679Nov 1, 1996Paper

Clinical correlates of bombesin-like peptide receptor subtype expression in human lung cancer cells

Lung Cancer : Journal of the International Association for the Study of Lung Cancer
M Toi-ScottM A Kane

Abstract

The importance of the expression of the autocrine growth system for bombesin-like peptides (BLPS) to the biological behavior of human lung cancer has not been determined. Three BLP receptor subtypes have been identified in human lung and lung cancer cells: gastrin-releasing peptide (GRP) receptor, neuromedin B (NMB) receptor, and bombesin receptor subtype 3 (BRS-3). The goals of this study were: (1) to determine BLP receptor subtype expression by human lung cancer cell lines by RT/PCR; (2) to evaluate possible clinical correlates of characteristics of the patients from whom the cell lines were derived with patterns of BLP receptor expression. Degenerate PCR primers were designed to amplify all known BLP receptors and yielded products from 19/20 small cell lung carcinoma (SCLC) and 12/13 non-small cell lung carcinoma (NSCLC) cell lines. GRP receptor was the most commonly expressed BLP receptor subtype, being detected in 17/20 SCLC and 11/13 NSCLC. Eleven of 20 SCLC expressed NMB receptors, and 5/20 expressed BRS-3, compared with 4/13 and 1/13, respectively, in NSCLC cell lines. Evaluation of the clinical data of the patients from whom the cell lines were derived revealed expected age, sex, smoking history and survival based on h...Continue Reading

References

Dec 2, 1992·International Journal of Cancer. Journal International Du Cancer·M MauriziG Cadoni
Apr 1, 1992·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·G ScambiaS Mancuso
Oct 1, 1989·The Journal of Clinical Investigation·S M AguayoY E Miller
Jan 1, 1985·The Journal of Clinical Investigation·S WeberT A Raffin
Nov 1, 1986·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·A G PedersenH H Hansen
Jan 1, 1988·Progress in Nucleic Acid Research and Molecular Biology·E Rozengurt, J Sinnett-Smith
May 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·D N CarneyJ D Minna
Jan 1, 1994·Journal of Cancer Research and Clinical Oncology·C WiltschkeP N Preis
Nov 1, 1994·International Journal of Cancer. Journal International Du Cancer·M A NagaiM M Brentani
Mar 1, 1994·Current Opinion in Oncology·G M Petersen
Jul 1, 1994·American Journal of Respiratory Cell and Molecular Biology·M A DeMicheleJ M Siegfried
Jan 2, 1994·International Journal of Cancer. Journal International Du Cancer·G ScambiaS Mancuso
Jan 1, 1996·Peptides·M A KaneA Escobedo-Morse

❮ Previous
Next ❯

Citations

Sep 6, 2002·Journal of Peptide Science : an Official Publication of the European Peptide Society·Dirk WeberHorst Kessler
Aug 19, 2010·European Journal of Nuclear Medicine and Molecular Imaging·Rosalba MansiHelmut R Maecke
May 12, 2009·Clinical & Experimental Metastasis·Claudio A RiveraRichard V Benya
Dec 31, 2003·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·John NovakMadeleine A Kane
Jul 6, 2000·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·J NovakM A Kane
Oct 30, 2004·Anti-cancer Drugs·Jiehua ZhouEdward D Ball
Mar 10, 2001·Nuclear Medicine Communications·C Van de WieleR A Dierckx
Jul 26, 2005·American Journal of Physiology. Lung Cellular and Molecular Physiology·Qihai Gu, Lu-Yuan Lee
Jun 17, 2003·American Journal of Respiratory and Critical Care Medicine·Meera SubramaniamMary E Sunday
Feb 9, 2007·European Journal of Nuclear Medicine and Molecular Imaging·M de VisserM de Jong
Jan 14, 2003·Seminars in Nuclear Medicine·Josef MachacChun Kim
Jun 1, 2011·Seminars in Nuclear Medicine·Samuel L RiceJason S Lewis
Feb 24, 2006·Biochimica Et Biophysica Acta·Oneel PatelGraham S Baldwin
Feb 2, 2011·The American Journal of Pathology·Robert TellRichard V Benya
Mar 12, 2015·Bioorganic & Medicinal Chemistry·Maral PourghiasianFrançois Bénard
Jul 12, 2016·Clinical Lung Cancer·Kathrin KahnertRudolf Maria Huber
Oct 18, 2005·Lancet·David M Jackman, Bruce E Johnson
Mar 30, 2017·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Natália JaegerCristina Bonorino
Dec 13, 2005·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Benjamin NismanTamar Peretz
Aug 16, 2003·Endocrine Reviews·Jean Claude Reubi
Feb 7, 2018·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Yan ZhangOlivier Civelli
May 6, 2017·Evidence-based Complementary and Alternative Medicine : ECAM·Chao FanYan Zhang
Jan 15, 2004·American Journal of Respiratory Medicine : Drugs, Devices, and Other Interventions·Christophe Van de WieleRudi Andre Dierckx
Apr 13, 2006·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Jiehua ZhouEdward D Ball
May 2, 2003·Journal of Medicinal Chemistry·Dirk WeberHorst Kessler

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.