Clinical correlates of cerebral white matter abnormalities in patients with Parkinson's disease

Parkinsonism & Related Disorders
Bibet L Ten HarmsenDaniel J van Wamelen

Abstract

To determine if autonomic dysfunction, cognitive disorders or axial disability are associated with white matter lesions (WML) in Parkinson disease (PD). We performed a retrospective cross-sectional review study on 204 consecutive PD patients who underwent cerebral MRI in our center between January 2012 and July 2016. For each patient, we scored the severity of WML and PV (periventricular) WML using the Fazekas score and using the ARWMC scale for WML and BG (basal ganglia) and clinical characteristics such as neurogenic orthostatic hypotension and cognitive function. 204 PD patients were included of whom n = 53 (26.0%) had neurogenic orthostatic hypotension (nOH). The presence of nOH was significantly associated with the severity of WML as defined by the Fazekas score and the ARWMC scale. An ordinal regression model confirmed this association with an OR of 0.41 (95% CI 0.18-0.92: p = .03) and an OR of 0.39 (95% CI 0.17-0.88: p = .02). There were no significant associations between WML and other co-variables, including hypertension, dopaminergic medication use, Hoehn and Yahr stage, gender and cognitive decline. The presence of nOH is associated with WML severity in PD patients.

Citations

Jun 8, 2018·Current Opinion in Neurology·Vittorio RispoliKailash P Bhatia
Dec 21, 2018·Expert Review of Neurotherapeutics·Danique L M RadderBastiaan R Bloem
Jun 24, 2020·Movement Disorders : Official Journal of the Movement Disorder Society·Joel RamirezUNKNOWN Ontario Neurodegenerative Disease Research Initiative Investigators
Sep 22, 2019·Brain Sciences·Bhavana Palakurthi, Sindhu Preetham Burugupally
Aug 11, 2020·Movement Disorders Clinical Practice·Mahsa DadarD Louis Collins
Jul 28, 2020·Journal of Parkinson's Disease·Alessandra FanciulliGregor K Wenning
Sep 29, 2020·Frontiers in Neurology·Katherine LongardnerIrene Litvan
Jul 25, 2018·Journal of Parkinson's Disease·Meltem CilizWalter Maetzler
Apr 14, 2021·Lancet·Bastiaan R BloemChristine Klein
Aug 8, 2021·Parkinsonism & Related Disorders·Daniel J van WamelenUNKNOWN International Parkinson and Movement Disorder Society Non Motor Parkinson's Disease Study Group
Feb 8, 2019·La Presse médicale·Emmanuelle MagnyCarmelo Lafuente-Lafuente

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