Clinical correlates of chronic cerebrospinal venous insufficiency in multiple sclerosis.

BMC Neurology
Bianca Weinstock-GuttmanR Zivadinov

Abstract

Chronic cerebrospinal venous insufficiency (CCSVI) is a vascular condition characterized by anomalies of the primary veins outside the skull that has been reported to be associated with MS. In the blinded Combined Transcranial (TCD) and Extracranial Venous Doppler Evaluation (CTEVD) study, we found that prevalence of CCSVI was significantly higher in multiple sclerosis (MS) vs. healthy controls (HC) (56.1% vs. 22.7%, p < 0.001).The objective was to evaluate the clinical correlates of venous anomalies indicative of CCSVI in patients with MS. The original study enrolled 499 subjects; 163 HC, 289 MS, 21 CIS and 26 subjects with other neurological disorders who underwent a clinical examination and a combined Doppler and TCD scan of the head and neck. This analysis was restricted to adult subjects with MS (RR-MS: n = 181, SP-MS: n = 80 and PP-MS: n = 12). Disability status was evaluated by using the Kurtzke Expanded Disability Status Scale (EDSS) and MS severity scale (MSSS). Disability was not associated with the presence (≥2 venous hemodynamic criteria) or the severity of CCSVI, as measured with venous hemodynamic insufficiency severity score (VHISS). However, the severity of CCSVI was associated with the increased brainstem funct...Continue Reading

References

Mar 3, 2006·The New England Journal of Medicine·Elliot M FrohmanCedric S Raine
Dec 9, 2008·Journal of Neurology, Neurosurgery, and Psychiatry·P ZamboniF Salvi
Jan 16, 2009·Journal of the Neurological Sciences·Paolo ZamboniFabrizio Salvi
Apr 3, 2009·Brain : a Journal of Neurology·Josa M FrischerHans Lassmann
Sep 3, 2009·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Ajay Vikram Singh, Paolo Zamboni
Dec 5, 2009·Journal of Vascular Surgery·Paolo ZamboniFabrizio Salvi
Aug 10, 2010·Annals of Neurology·Florian DoeppStephan J Schreiber
Nov 3, 2010·Multiple Sclerosis : Clinical and Laboratory Research·Bassem YamoutAghiab Al-Kutoubi
Feb 1, 2011·Annals of Neurology·Claudio BaracchiniPaolo Gallo
Feb 8, 2011·Journal of Neurology, Neurosurgery, and Psychiatry·Christoph A MayerUlf Ziemann
Jul 16, 2011·AJNR. American Journal of Neuroradiology·G ZaharchukM D Dake
Aug 9, 2011·Journal of the Neurological Sciences·E AurielH Hallevi
Aug 10, 2011·Archives of Neurology·Ellen MarderOlaf Stüve

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Citations

Oct 24, 2014·Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging·Eytan RazFrancesca Caramia
Oct 1, 2013·Multiple Sclerosis and Related Disorders·Marian SimkaMaciej Zaniewski
May 29, 2013·Multiple Sclerosis : Clinical and Laboratory Research·Robert Zivadinov, Bianca Weinstock-Guttman

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