Clinical correlates of monospecific anti-PM75 and anti-PM100 antibodies in a tri-nation cohort of 1574 systemic sclerosis subjects

Autoimmunity
Michael WodkowskiMarvin J Fritzler

Abstract

Autoantibodies directed against the two principal antigens of the human exosome complex, PM75 and PM100, are present in systemic sclerosis (SSc) sera and have been associated with myositis and calcinosis. However, there is a paucity of data on the clinical correlates of these autoantibodies separately and in the absence of other SSc-specific antibodies. The aim of this study was to assess the clinical correlates of monospecific anti-PM75 and anti-PM100 in SSc. A tri-nation cohort of 1574 SSc subjects was formed, clinical variables were harmonized and sera were tested for anti-PM75 and anti-PM100 antibodies using a line immunoassay. Forty-eight (3.0%) subjects had antibodies against PM75 and 18 (1.1%) against PM100. However, only 16 (1%) had monospecific anti-PM75 antibodies and 11 (0.7%) monospecific anti-PM100 antibodies (i.e. in isolation of each other and other SSc-specific antibodies). Monospecific profiles of each autoantibody included more calcinosis. An increased frequency of myositis was only seen in subjects positive for both anti-PM75 and anti-PM100 antibodies. Lung disease was only associated with anti-PM75 and subjects with anti-PM100 antibodies had better survival compared to other antibody subsets. The prevalence ...Continue Reading

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Citations

Sep 2, 2016·Medicine·S HoaUNKNOWN Canadian Scleroderma Research Group (CSRG); Australian Scleroderma Interest Group (ASIG); Genetics versus Environment in Scl
Jul 28, 2017·Autoimmunity·Christos LiaskosLazaros I Sakkas
Apr 4, 2017·The Journal of Rheumatology·Carolina Mejia OteroUNKNOWN Genetics versus Environment in Scleroderma Outcome Study
Jun 28, 2019·International Journal of Rheumatic Diseases·Yasuhito HamaguchiKazuhiko Takehara
Apr 11, 2018·Frontiers in Immunology·Kevin DidierAmelie Servettaz
Jun 11, 2021·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Chloé BostYves Renaudineau
May 17, 2021·The Journal of Rheumatology·Tatiana NevskayaSindhu R Johnson

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