Clinical correlates of Parkinsonian signs in community- dwelling Chinese older persons: a population based study

International Journal of Geriatric Psychiatry
C W C TamW M Chan

Abstract

This study examined the clinical correlates of parkinsonian signs including neuropsychiatric symptoms, cognitive impairment and medical illness burden in the community-dwelling non-demented Chinese elderly. A random sample of 765 Chinese elderly subjects from a thematic household survey was recruited. There were 389 normal elderly controls (Clinical Dementia Rating [CDR] 0) (NC) and 376 subjects with questionable dementia (CDR 0.5). The subjects with questionable dementia (CDR 0.5) were categorized into two groups: a MCI group (n = 291) and a very mild dementia (VMD) group (n = 85). Parkinsonian signs were measured by Unified Parkinson Disease Rating Scale- motor scale (UPDRS). The clinical correlates were investigated in each group. UPDRS motor score was associated with age, cumulative medical illness burden and cerebrovascular accidents in the normal control and MCI groups. It correlated negatively with MMSE scores in the NC group. It was associated with presence of soft signs in the NC and MCI groups; and apathy in the VMD group. Neuropsychiatric symptoms, cognitive impairment and vascular risk factors had different patterns of associations with parkinsonian signs in the older persons with different degree of cognitive impai...Continue Reading

References

Jul 1, 1990·Trends in Neurosciences·G E Alexander, M D Crutcher
Jun 1, 1982·The British Journal of Psychiatry : the Journal of Mental Science·C P HughesR L Martin
Jan 1, 1993·Journal of the American Geriatrics Society·Y ConwellE D Caine
Jan 11, 1996·The New England Journal of Medicine·D A BennettD A Evans
Mar 1, 1997·Annals of Neurology·Y LiuJ E Goldman
Mar 20, 2001·Archives of Neurology·J C MorrisL Berg
Sep 6, 2001·International Journal of Geriatric Psychiatry·V P LeungQ L Chen
Oct 10, 2002·Neurology·Martha StorandtJohn C Morris
Dec 10, 2002·Acta Neuropathologica·Kurt A Jellinger, Johannes Attems
Apr 6, 2004·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·S PapapetropoulosT Papapetropoulos
Jun 16, 2004·Movement Disorders : Official Journal of the Movement Disorder Society·Jan C M ZijlmansAndrew J Lees
Aug 18, 2004·Archives of Neurology·Elan D LouisRichard Mayeux
Aug 25, 2004·Journal of Internal Medicine·R C Petersen
Sep 2, 2004·Journal of Neural Transmission·C PeraltaW Poewe
Dec 2, 2004·Dementia and Geriatric Cognitive Disorders·Linda C W LamCindy W C Tam
Aug 24, 2005·International Journal of Geriatric Psychiatry·Linda C W LamHelen F K Chiu
Dec 29, 2005·Neurology·P A BoyleD A Bennett
Apr 28, 2006·Current Opinion in Psychiatry·Uwe Ehrt, Dag Aarsland
May 10, 2006·Archives of Neurology·Elan D Louis, Jose A Luchsinger
Jul 14, 2006·Dementia and Geriatric Cognitive Disorders·Linda Chiu Wa LamCindy Woon Chi Tam
Sep 26, 2007·International Psychogeriatrics·Linda C W LamHelen F K Chiu

❮ Previous
Next ❯

Citations

Mar 27, 2019·Brain Sciences·David ShprecherRodolfo Savica
Sep 26, 2021·Movement Disorders : Official Journal of the Movement Disorder Society·Sarah M BuchananAnette Schrag

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.