PMID: 11921500Mar 30, 2002Paper

Clinical correlates of prolonged pain in Japanese patients with acute herpes zoster

The Journal of International Medical Research
I KurokawaHyogo Prefectural PHN Study Group

Abstract

To determine which risk factors are relevant to the occurrence of post-herpetic neuralgia in Japanese patients with acute herpes zoster, correlations between the prolongation of pain and various disease factors were examined in 263 adult patients presenting within 10 days of the onset of rash at 17 institutions in the Hyogo region of Japan. All patients in whom pain persisted for more than 3 months were over 60 years of age. The pain also tended to be more prolonged in those with clustered vesicles, disturbed sleep and hypanaesthesia. Other factors such as underlying disease states, critically involved regions, scar tissue, generalized rash and allodynia were not relevant to the duration of pain. Although decreased pain persistence was observed in patients in whom acyclovir therapy was initiated within 72 h of the onset of symptoms in comparison with those in whom it was initiated after this time, the difference between the two groups of patients was not statistically significant. Our results suggest that advanced age, the presence of clustered vesicles, and disturbed sleep and hypanaesthesia influence the prolongation of herpes zoster pain.

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Citations

Aug 26, 2003·Advanced Drug Delivery Reviews·David Borsook, Lino Becerra
Dec 5, 2006·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Robert H DworkinRichard J Whitley
Jan 3, 2012·The Clinical Journal of Pain·Yuko KanbayashiToyoshi Hosokawa
Oct 31, 2012·International Journal of General Medicine·Monica TontodonatiGiustino Parruti
Dec 3, 2013·Expert Opinion on Pharmacotherapy·Sharon R KimStephen K Tyring
Apr 7, 2015·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Kosuke KawaiCamilo J Acosta
Jan 31, 2008·The Journal of Pain : Official Journal of the American Pain Society·Kenneth E Schmader, Robert H Dworkin
Dec 6, 2012·The British Journal of General Practice : the Journal of the Royal College of General Practitioners·Harriet J ForbesSinéad M Langan
Apr 30, 2013·Expert Review of Neurotherapeutics·Sabine BoogaardRoberto S G M Perez
May 20, 2020·The Journal of Dermatology·Naoko ShojiUNKNOWN Amenamevir Review Team
Mar 17, 2017·BMC Infectious Diseases·Liang-Kung ChenChang Won Won

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