Clinical correlates to assist with chronic traumatic encephalopathy diagnosis: Insights from a novel rodent repeat concussion model

The Journal of Trauma and Acute Care Surgery
Gretchen M ThomsenEric J Ley

Abstract

Chronic traumatic encephalopathy (CTE) is a neurodegenerative disease linked to repetitive head injuries. Chronic traumatic encephalopathy symptoms include changes in mood, behavior, cognition, and motor function; however, CTE is currently diagnosed only postmortem. Using a rat model of recurrent traumatic brain injury (TBI), we demonstrate rodent deficits that predict the severity of CTE-like brain pathology. Bilateral, closed-skull, mild TBI was administered once per week to 35 wild-type rats; eight rats received two injuries (2×TBI), 27 rats received five injuries (5×TBI), and 13 rats were sham controls. To determine clinical correlates for CTE diagnosis, TBI rats were separated based on the severity of rotarod deficits and classified as "mild" or "severe" and further separated into "acute," "short," and "long" based on age at euthanasia (90, 144, and 235 days, respectively). Brain atrophy, phosphorylated tau, and inflammation were assessed. All eight 2×TBI cases had mild rotarod deficiency, 11 5×TBI cases had mild deficiency, and 16 cases had severe deficiency. In one cohort of rats, tested at approximately 235 days of age, balance, rearing, and grip strength were significantly worse in the severe group relative to both sha...Continue Reading

References

May 1, 1990·Journal of Neurology, Neurosurgery, and Psychiatry·G W RobertsC Bruton
Aug 1, 1973·Psychological Medicine·J A CorsellisD Freeman-Browne
Feb 1, 1995·Journal of Neurotrauma·D M BassoJ C Bresnahan
Mar 23, 2007·Journal of Neurotrauma·Andrew I R MaasEwout W Steyerberg
Mar 14, 2009·The Journal of Biological Chemistry·Bess FrostMarc I Diamond
Jun 9, 2009·Nature Cell Biology·Florence ClavagueraMarkus Tolnay
Jun 19, 2009·Journal of Neuropathology and Experimental Neurology·Ann C McKeeRobert A Stern
Aug 20, 2010·Journal of Neuropathology and Experimental Neurology·Ann C McKeeAndrew E Budson
Aug 16, 2011·Clinical Neurology and Neurosurgery·Maryam FourtassiAbdeslam El Khamlichi
Sep 3, 2011·Surgical Neurology International·Russell L Blaylock, Joseph Maroon
Oct 11, 2012·Scientific Reports·Cristian A Lasagna-ReevesRakez Kayed
Dec 5, 2012·Brain : a Journal of Neurology·Ann C McKeeRobert C Cantu
Jan 22, 2013·Journal of Neuropathology and Experimental Neurology·Joseph-Olubunmi OjoFiona Crawford
Feb 26, 2013·The Journal of Clinical Investigation·Jeffrey J IliffHelene Benveniste
Aug 24, 2013·Neurology·Robert A SternAnn C McKee
Dec 5, 2014·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Jeffrey J IliffMaiken Nedergaard
Jan 16, 2015·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Benjamin A PlogMaiken Nedergaard
Feb 17, 2015·Molecular and Cellular Neurosciences·David L BrodyChristine L Mac Donald
Apr 24, 2015·Brain Pathology·Ann C McKeeVictor E Alvarez
Aug 12, 2015·Current Pain and Headache Reports·Thor D SteinAnn C McKee
Nov 6, 2015·Frontiers in Neurology·Ryan C TurnerAnthony L Petraglia
Jul 28, 2016·Journal of Neuroscience Research·Shenandoah RobinsonLauren L Jantzie
Jul 28, 2016·PloS One·Alex P Di BattistaMichael G Hutchison
Sep 8, 2016·The Journal of Trauma and Acute Care Surgery·Gretchen M ThomsenEric J Ley

❮ Previous
Next ❯

Citations

Nov 2, 2019·Brain : a Journal of Neurology·Grant L IversonRudolph J Castellani
May 31, 2020·The Journal of Trauma and Acute Care Surgery·Navpreet K DhillonEric J Ley

❮ Previous
Next ❯

Related Concepts

Related Feeds

Brain Injury & Trauma

brain injury after impact to the head is due to both immediate mechanical effects and delayed responses of neural tissues.

Barrel cortex

Here is the latest research on barrel cortex, a region of somatosensory and motor corticies in the brain, which are used by animals that rely on whiskers for world exploration.