Clinical correlation of extensive-stage small-cell lung cancer genomics

Annals of Oncology : Official Journal of the European Society for Medical Oncology
A DowlatiG Wildey

Abstract

Genomic studies in small-cell lung cancer (SCLC) lag far behind those carried out in nonsmall-cell lung cancer (NSCLC). To date, most SCLC studies have evaluated patients with surgically resectable disease. Here we sought to evaluate the genomic mutation spectrum of 'every-day' SCLC patient tumors with extensive stage disease (ES-SCLC) and to correlate mutations with the main clinical outcomes of response to chemotherapy, progression-free (PFS) and overall (OS) survival. A total of 50 SCLC patient tumors were examined in this study; targeted exome sequencing was obtained on 42 patients and whole-exome sequencing on 8 patients. Mutated genes were correlated with clinical outcomes using Kaplan-Meier methods (PFS, OS) and logistic regression (chemo-response). RB1 protein expression was detected by either western blotting of cultured cell lysates or immunohistochemistry of tumor specimens. In all, 39 patients had ES-SCLC; 15 patients had either primary refractory/resistant disease and 21 patients had sensitive disease. The two most frequently mutated genes were TP53 (86%) and RB1 (58%); other frequently mutated genes (>10% patients) were involved in epigenetic regulation as well as the mTOR pathway. We identified a number of low-fr...Continue Reading

References

Sep 30, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Ramaswamy GovindanJay Piccirillo
Aug 31, 2010·Journal of the American Academy of Dermatology·Julie K IwasakiDavid J Kouba
Nov 16, 2011·Laboratory Investigation; a Journal of Technical Methods and Pathology·Mayumi NakaiSeiichi Hirota
Jul 20, 2012·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Agnieszka K WitkiewiczErik S Knudsen
Jan 12, 2013·Journal of the National Comprehensive Cancer Network : JNCCN·Gregory P KalemkerianUNKNOWN National Comprehensive Cancer Network
Feb 4, 2014·Clinical Lung Cancer·Myles NickolichAfshin Dowlati
Apr 4, 2014·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Miguel A Molina-VilaRafael Rosell
Aug 15, 2014·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Snehal DabirAfshin Dowlati
Aug 15, 2014·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Shigeki UmemuraKoichi Goto
May 17, 2015·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·M Catherine PietanzaCharles M Rudin
Jul 15, 2015·Nature·Julie GeorgeRoman K Thomas

❮ Previous
Next ❯

Citations

Dec 23, 2016·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Arnaud AugertDavid MacPherson
Feb 19, 2019·Cancer Medicine·Priyanka BhatejaAfshin Dowlati
Feb 15, 2019·Journal of Computer Assisted Tomography·Xin LiNikhil H Ramaiya
Jun 26, 2020·Cancer·Asrar AlAhmadi, Afshin Dowlati
Dec 29, 2018·Expert Review of Anticancer Therapy·Lizza E L HendriksMartin Reck
Apr 26, 2019·Journal of Hematology & Oncology·Lin MeiJingsong Zhang
May 24, 2017·Nature Reviews. Clinical Oncology·Joshua K SabariCharles M Rudin
Apr 24, 2019·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·William S ChenFelix Y Feng
Oct 27, 2017·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Jules L DerksUNKNOWN PALGA-Group
May 3, 2016·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Sandra Cristea, Julien Sage
May 23, 2021·Revue des maladies respiratoires·C BasseN Girard
Jun 23, 2021·Biochemical Society Transactions·Lan-Hsin WangShu-Ping Wang
Jun 18, 2021·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Jules L DerksAnne-Marie C Dingemans

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cancer Epigenetics & Metabolism (Keystone)

Epigenetic changes are present and dysregulated in many cancers, including DNA methylation, non-coding RNA segments and post-translational protein modifications. The epigenetic changes may or may not provide advantages for the cancer cells. This feed focuses on the relationship between cell metabolism, epigenetics and tumor differentiation.

Cancer Epigenetics and Senescence (Keystone)

Epigenetic changes are present and dysregulated in many cancers, including DNA methylation, non-coding RNA segments and post-translational protein modifications. The epigenetic changes may be involved in regulating senescence in cancer cells. This feed captures the latest research on cancer epigenetics and senescence.

Cancer Genomics (Keystone)

Cancer genomics approaches employ high-throughput technologies to identify the complete catalog of somatic alterations that characterize the genome, transcriptome and epigenome of cohorts of tumor samples. Discover the latest research using such technologies in this feed.