Clinical correlation of molecular (VEGF, FGF, PDGF, c-Myc, c-Kit, Ras, p53) expression in juvenile nasopharyngeal angiofibroma

European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
Anupam MishraAmita Pandey

Abstract

A molecular surrogate may exist for the clinical behaviour of juvenile nasopharyngeal angiofibroma (JNA). In 9-14 cases, a 'correlation' of clinical behaviour with molecular expression (m-RNA expression through RT-PCR) of VEGF, FGF, PDGF, Ras, c-Myc, c-Kit and p53 was undertaken. A comparison of the two extremes of expressions characterized some specific clinical phenotypes for every marker except c-Myc. A higher FGF was associated with post-adolescent presentation, smaller tumour size, enhanced haemorrhage and recurrence. A higher c-Kit was associated with adolescents, rapid growth, skull base involvement and recurrence. Enhanced Ras was associated with post-adolescence, smaller tumour size, skull base involvement and recurrence. Enhanced p53 and PDGF were associated with adolescents, early presentation and rapid progression. Higher VEGF expression was associated with skull base involvement and enhanced haemorrhage. This study is currently the only evidence revealing a clinical molecular association in JNA and larger multicentric studies need to be performed to show a statistical significance.

References

Jan 1, 1992·Annual Review of Biochemistry·K B MarcuA J Patel
Sep 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·A B SchreiberT Maciag
Oct 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·K A ThomasS Fitzpatrick
Oct 1, 1989·The Journal of Laryngology and Otology·S C MishraM C Pant
Oct 1, 1982·The Journal of Cell Biology·S K LemmonR A Bradshaw
Feb 1, 1996·Archives of Otolaryngology--head & Neck Surgery·D RadkowskiD T Jones
May 1, 1996·European Journal of Cancer. Part B, Oral Oncology·I C PatersonS S Prime
Sep 4, 1998·Science·T C HeK W Kinzler
Oct 8, 1999·São Paulo Medical Journal = Revista Paulista De Medicina·C M CoutinhoM A Nagai
Jun 23, 2000·Archives of Otolaryngology--head & Neck Surgery·D G DillardA A Gal
Dec 18, 2001·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Z K ArbiserA A Gal
Aug 17, 2002·Genes & Development·Nesrin M HamadChristopher M Counter
Jan 2, 2003·Nature Reviews. Cancer·Julian Downward
Mar 18, 2003·Molecular and Cellular Biology·Philip J MitchellAlison C Lloyd
Jun 17, 2004·Genes & Development·Owen J SansomDouglas J Winton
Jun 24, 2004·Archives of Otolaryngology--head & Neck Surgery·Jürgen BriegerWolf J Mann
Jun 14, 2005·Cancer Cell·Kian-Huat LimChristopher M Counter
Jul 19, 2005·International Journal of Pediatric Otorhinolaryngology·Güleser SaylamMetin Onerci
Dec 21, 2006·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Robert SchuonWolf J Mann
Apr 11, 2007·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Ana López-MartinLuis Paz-Ares
May 17, 2008·Genes & Development·Johanna AndraeChrister Betsholtz
Aug 21, 2008·Neoplasia : an International Journal for Oncology Research·Christoph WiesnerR Daniel Bonfil
Jun 6, 2009·American Journal of Respiratory and Critical Care Medicine·Varsha V GupteSaverio Bellusci
Jan 20, 2012·Fibrogenesis & Tissue Repair·Irina G Luzina, Sergei P Atamas
Jun 2, 2012·Frontiers in Bioscience (Landmark Edition)·Li XiaoZhenhua Li
Sep 18, 2012·Expert Opinion on Therapeutic Targets·Domenico RibattiAngelo Vacca
Apr 23, 2013·Genes to Cells : Devoted to Molecular & Cellular Mechanisms·Emi MatsumotoNobuyuki Itoh
Apr 26, 2013·Critical Reviews in Oncogenesis·Valentina Profumo, Paolo Gandellini
Oct 3, 2013·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·Pan ChengZhou-Cun A
Aug 19, 2014·Molecular and Cellular Endocrinology·Biff F Palmer, Deborah J Clegg
Jul 8, 2017·The Journal of Laryngology and Otology·A MishraS C Mishra
Nov 6, 2018·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Anupam MishraS C Mishra
Jan 9, 2019·Journal of Oral Biology and Craniofacial Research·Anupam Mishra, Veerendra Verma

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Citations

Nov 6, 2018·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Anupam MishraS C Mishra
Jan 12, 2020·Pediatric Blood & Cancer·Karen S FernándezAdrienne M Hammill
Dec 7, 2018·Current Opinion in Otolaryngology & Head and Neck Surgery·Giacomo BertazzoniPiero Nicolai

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