Clinical correlation with the PA/plasmin system in septic arthritis of the knee

Clinical Orthopaedics and Related Research
Yih-Shou HsiehKo-Hsiu Lu

Abstract

Substantially more gelatinases appear in effusions of septic arthritis than in effusions of aseptic arthritis. We hypothesized there is greater plasminogen activator/plasmin activity in effusions of septic arthritis than aseptic arthritis. We examined the antigenic values of urokinase-type plasminogen activator and plasminogen activator inhibitor Type-1, cell counts, and levels of matrix metalloproteinase-2 and metalloproteinase-9 in 135 knee effusions from 80 patients with septic arthritis, rheumatoid arthritis, gouty arthritis, and osteoarthritis. Urokinase-type plasminogen activator and plasminogen activator inhibitor Type-1 antigenic values in effusions of septic arthritis were greater than those in effusions of aseptic arthritis. The increases of urokinase-type plasminogen activator and plasminogen activator inhibitor Type-1 antigenic values in effusions were associated with increased levels of prometalloproteinase-9 and the appearance of activated metalloproteinase-2. Antigenic values of urokinase-type plasminogen activator also correlated with the appearance of activated metalloproteinase-9. High plasminogen activator/plasmin activity, prometalloproteinase-9 levels, and the presence of activated metalloproteinase-2 and m...Continue Reading

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Citations

Sep 13, 2014·The Journal of Infectious Diseases·Sana DastgheybMichael Otto
Nov 3, 2007·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Yih-Shou HsiehKo-Hsiu Lu
Oct 6, 2007·Current Opinion in Rheumatology
Aug 12, 2010·Clinica Chimica Acta; International Journal of Clinical Chemistry·Shu-chen ChuKo-hsiu Lu

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